Calcipressin

Calcipressin
solution structure of rrm domain in calcipressin 1
Identifiers
Symbol	Calcipressin
Pfam	PF04847
Pfam clan	CL0221
InterPro	IPR006931
Available protein structures: PDB   IPR006931 PF04847 (ECOD; PDBsum)   AlphaFold IPR006931 PF04847

In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.

In humans, the Calcipressins family of proteins is derived from three genes:

• Calcipressin 1 (encoded by RCAN1) is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1).
• Calcipressin 2 (encoded by RCAN2) is variously known as MCIP2, ZAKI-4 and DSCR1-like 1.
• Calcipressin 3 (encoded by RCAN3) is also called MCIP3 and DSCR1-like 2.

References