RCAN3

RCAN3
Identifiers
Aliases	RCAN3, DSCR1L2, MCIP3, RCN3, hRCN3, RCAN family member 3
External IDs	OMIM: 605860; MGI: 1858220; GeneCards: RCAN3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,541,040 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,161,164 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; epithelium of nasopharynx; ; sperm; ; cerebellar vermis; ; skin of thigh; ; gingival epithelium; ; corpus epididymis; ; skin of hip; ; parotid gland; ; oral cavity;
	Top expressed in
	zygote; ; secondary oocyte; ; islet of Langerhans; ; ventral tegmental area; ; vestibular membrane of cochlear duct; ; dorsal tegmental nucleus; ; primary oocyte; ; dorsomedial hypothalamic nucleus; ; central gray substance of midbrain; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; troponin I binding; calcium-dependent protein serine/threonine phosphatase regulator activity; RNA binding; nucleic acid binding; phosphatase binding;
Cellular component	cytoplasm;
Biological process	regulation of calcineurin-NFAT signaling cascade; anatomical structure morphogenesis; calcium-mediated signaling; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11123
	53902
	ENSG00000117602
	ENSMUSG00000059713
	Q9UKA8
	Q9JKK0
NM_013441; NM_001251977; NM_001251978; NM_001251979; NM_001251980;
	NM_001251981; NM_001251982; NM_001251983; NM_001251984; NM_001251985
	NM_022980
NP_001238906; NP_001238907; NP_001238908; NP_001238909; NP_001238910;
	NP_001238911; NP_001238912; NP_001238913; NP_001238914; NP_038469
	NP_075356
	Wikidata
View/Edit Human	View/Edit Mouse

RCAN3 is a gene that in humans encodes the Calcipressin-3 protein.

Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the Calcipressin family of proteins.

Expression

RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus.

Orthologs

RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).

Clinical significance

Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down syndrome in humans.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117602 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059713 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.
↑ "Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2".
↑ "Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)". genome.ucsc.edu. Retrieved 2020-06-11.
↑ "RCAN3 Gene - GeneCards | RCAN3 Protein | RCAN3 Antibody". www.genecards.org. Retrieved 2020-06-11.
↑ "InterPro". www.ebi.ac.uk. Retrieved 2020-06-11.

Facchin F, Canaider S, Vitale L, et al. (2008). "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms". Gene. 407 (1–2): 159–68. doi:10.1016/j.gene.2007.10.006. PMID 18022329.
Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M (2007). "RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression". Biochim. Biophys. Acta. 1773 (3): 330–41. doi:10.1016/j.bbamcr.2006.12.007. PMID 17270291.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Canaider S, Facchin F, Griffoni C, et al. (2006). "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)". Gene. 372: 128–36. doi:10.1016/j.gene.2005.12.029. hdl:11586/196835. PMID 16516408.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117602 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059713 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10756093-5] Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M (May 2000). "A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)". Genomics. 64 (3): 252–63. doi:10.1006/geno.2000.6127. PMID 10756093.

[entrez-6] "Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2".

[7] "Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3)". genome.ucsc.edu. Retrieved 2020-06-11.

[8] "RCAN3 Gene - GeneCards | RCAN3 Protein | RCAN3 Antibody". www.genecards.org. Retrieved 2020-06-11.

[9] "InterPro". www.ebi.ac.uk. Retrieved 2020-06-11.

RCAN3

Expression

Orthologs

Clinical significance

See also

References

Further reading