Carumonam

Carumonam
Clinical data
Trade names	Amasulin
AHFS/Drugs.com	International Drug Names
ATC code	J01DF02 (WHO) ;
Identifiers
	IUPAC name 2-[(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-(carbamoyloxymethyl)-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acid;
CAS Number	87638-04-8 ;
PubChem CID	6540466;
DrugBank	DB13553 ;
ChemSpider	5022832 ;
UNII	486890PI06;
ChEBI	CHEBI:55486;
ChEMBL	ChEMBL1614658 ;
CompTox Dashboard (EPA)	DTXSID3048312 ;
Chemical and physical data
Formula	C12H14N6O10S2
Molar mass	466.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=C(N=C(S1)N)/C(=N/OCC(=O)O)/C(=O)N[C@H]2[C@H](N(C2=O)S(=O)(=O)O)COC(=O)N;
	InChI InChI=1S/C12H14N6O10S2/c13-11-15-4(3-29-11)7(17-28-2-6(19)20)9(21)16-8-5(1-27-12(14)23)18(10(8)22)30(24,25)26/h3,5,8H,1-2H2,(H2,13,15)(H2,14,23)(H,16,21)(H,19,20)(H,24,25,26)/b17-7-/t5-,8+/m1/s1 ; Key:UIMOJFJSJSIGLV-JNHMLNOCSA-N ;
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Carumonam (INN) is a monobactam antibiotic previously sold in Japan under the brand name Amasulin. One of only four members of its class, Carumonam was withdrawn sometime before 2021, leaving only Aztreonam on the market. It is very resistant to beta-lactamases, which means that it is more difficult for bacteria to break down using β-lactamase enzymes.

References

↑ McNulty CA, Garden GM, Ashby J, Wise R (September 1985). "Pharmacokinetics and tissue penetration of carumonam, a new synthetic monobactam". Antimicrobial Agents and Chemotherapy. 28 (3): 425–7. doi:10.1128/aac.28.3.425. PMC 180266. PMID 4073864.
↑ Hara, Takuji (1997). "Industrial Technological Trajectories and Corporate Technology Traditions : The Development of Antibacterial Drugs in Japan". The Annals of the School of Business Administration, Kobe University. 41: 1–18. doi:10.24546/81003680.
↑ "Monobactam Derivative - an overview". ScienceDirect. Elsevier. Retrieved 4 August 2026.
↑ "ATC/DDD Index 2026: Carumonam (J01DF02)". WHO Collaborating Centre for Drug Statistics Methodology. 15 December 2011. Retrieved 4 August 2026.
↑ PubChem. "Carumonam". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-12-08.

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[1] McNulty CA, Garden GM, Ashby J, Wise R (September 1985). "Pharmacokinetics and tissue penetration of carumonam, a new synthetic monobactam". Antimicrobial Agents and Chemotherapy. 28 (3): 425–7. doi:10.1128/aac.28.3.425. PMC 180266. PMID 4073864.

[2] Hara, Takuji (1997). "Industrial Technological Trajectories and Corporate Technology Traditions : The Development of Antibacterial Drugs in Japan". The Annals of the School of Business Administration, Kobe University. 41: 1–18. doi:10.24546/81003680.

[3] "Monobactam Derivative - an overview". ScienceDirect. Elsevier. Retrieved 4 August 2026.

[4] "ATC/DDD Index 2026: Carumonam (J01DF02)". WHO Collaborating Centre for Drug Statistics Methodology. 15 December 2011. Retrieved 4 August 2026.

[5] PubChem. "Carumonam". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-12-08.