Cefatrizine

Cefatrizine
Clinical data
Trade names	Cefaperos, Zanitrin
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	J01DB07 (WHO) ;
Identifiers
	IUPAC name (6R,7R)-7-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	51627-14-6 ;
PubChem CID	6410758;
ChemSpider	4918615 ;
UNII	8P4W949T8K;
KEGG	D02711 ;
ChEBI	CHEBI:131730 ;
ChEMBL	ChEMBL1095284 ;
CompTox Dashboard (EPA)	DTXSID7022752 ;
ECHA InfoCard	100.052.096
Chemical and physical data
Formula	C18H18N6O5S2
Molar mass	462.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)[C@@H](c3ccc(O)cc3)N)CSc4nn[nH]c4)C(=O)O;
	InChI InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1 ; Key:UOCJDOLVGGIYIQ-PBFPGSCMSA-N ;
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Cefatrizine is a first generation broad-spectrum cephalosporin antibiotic that was developed in the 1970's by GSK plc. It was sold commercially by Bristol Myers Squibb in France as Cefaperos and in Pakistan as Zanitrin, though the subject of some clinical trials in the United States, it was never brought to market there.

References

↑ Dunn GL, Hoover JR, Berges DA, Taggart JJ, Davis LD, Dietz EM, et al. (January 1976). "Orally active 7-phenylglycyl cephalosporins. Structure-activity studies related to cefatrizine (SK&F 60771)". The Journal of Antibiotics. 29 (1). Tokyo: 65–80. doi:10.7164/antibiotics.29.65. PMID 776915.
↑ US 3867380, Dunn GL, Hoover JR, "3-Heterocyclic thio-methylcephalosporins", published 1975-02-18, issued 1975-02-18, assigned to SmithKline Corporation and SmithKline Beecham Corp
↑ "CEFAPEROS 500 mg, gélule" (in French). ANSM. Retrieved August 5, 2026.
1 2 "Bristol-Myers Squibb Co. Form 10-K Annual Report for the Fiscal Year Ended December 31, 1993". U.S. Securities and Exchange Commission. March 31, 1994. Retrieved August 5, 2026.
↑ "Bristol-Myers Squibb Co. Form 10-K Annual Report for the Fiscal Year Ended December 31, 1994". U.S. Securities and Exchange Commission. March 29, 1995. Retrieved August 5, 2026.
↑ Doran RG, Brumfitt W, Hamilton-Miller JM (1976). "Antibacterial Activity of Cefatrizine (BL-S 640), a New Oral Cephalosporin, In Vitro". Antimicrobial Agents and Chemotherapy. 9 (3): 397–402. doi:10.1128/aac.9.3.397. PMC 429517. PMID 1273064.

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[1] Dunn GL, Hoover JR, Berges DA, Taggart JJ, Davis LD, Dietz EM, et al. (January 1976). "Orally active 7-phenylglycyl cephalosporins. Structure-activity studies related to cefatrizine (SK&F 60771)". The Journal of Antibiotics. 29 (1). Tokyo: 65–80. doi:10.7164/antibiotics.29.65. PMID 776915.

[2] US 3867380, Dunn GL, Hoover JR, "3-Heterocyclic thio-methylcephalosporins", published 1975-02-18, issued 1975-02-18, assigned to SmithKline Corporation and SmithKline Beecham Corp

[3] "CEFAPEROS 500 mg, gélule" (in French). ANSM. Retrieved August 5, 2026.

[Bristol_Myers_Squibb_1994-4] 1 2 "Bristol-Myers Squibb Co. Form 10-K Annual Report for the Fiscal Year Ended December 31, 1993". U.S. Securities and Exchange Commission. March 31, 1994. Retrieved August 5, 2026.

[5] "Bristol-Myers Squibb Co. Form 10-K Annual Report for the Fiscal Year Ended December 31, 1994". U.S. Securities and Exchange Commission. March 29, 1995. Retrieved August 5, 2026.

[6] Doran RG, Brumfitt W, Hamilton-Miller JM (1976). "Antibacterial Activity of Cefatrizine (BL-S 640), a New Oral Cephalosporin, In Vitro". Antimicrobial Agents and Chemotherapy. 9 (3): 397–402. doi:10.1128/aac.9.3.397. PMC 429517. PMID 1273064.