Caspase 5

CASP5
Identifiers
Aliases	CASP5, ICE(rel)III, ICEREL-III, ICH-3, caspase 5
External IDs	OMIM: 602665; MGI: 107700; GeneCards: CASP5
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	105,023,168 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	5,336,783 bp
RNA expression pattern
	Top expressed in
	rectum; ; testicle; ; monocyte; ; blood; ; appendix; ; mucosa of transverse colon; ; granulocyte; ; mucosa of sigmoid colon; ; duodenum; ; spleen;
	Top expressed in
	granulocyte; ; jejunum; ; ileum; ; duodenum; ; large intestine; ; Paneth cell; ; colon; ; endothelial cell of lymphatic vessel; ; uterus; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; scaffold protein binding; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; protein binding;
Cellular component	NLRP3 inflammasome complex; AIM2 inflammasome complex; IPAF inflammasome complex; NLRP1 inflammasome complex; soma; neuron projection; cytoplasm;
Biological process	regulation of apoptotic process; ectopic germ cell programmed cell death; cellular response to mechanical stimulus; substantia nigra development; pyroptosis; proteolysis; regulation of inflammatory response; apoptotic process; execution phase of apoptosis; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	838
	12363
	ENSG00000137757
	ENSMUSG00000033538
	P51878
	P70343
	NM_001136109; NM_001136110; NM_001136112; NM_004347
	NM_007609
	NP_001129581; NP_001129582; NP_001129584; NP_004338
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 5 is an enzyme that in humans is encoded by the CASP5 gene. This enzyme proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. It is an inflammatory caspase, along with caspase 1, caspase 4 and the murine caspase 4 homolog caspase 11, and has a role in the immune system.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137757 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033538 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.

External links

The MEROPS online database for peptidases and their inhibitors: C14.008^{[link removed]}

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137757 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033538 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.

v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Caspase 5

See also

References

External links