The genus was first described by Travassos, Artigas & Pereira in 1928.
Its type-species is Creptotrema creptotrema Travassos, Artigas & Pereira, 1928.
According to a molecular and morphological study by Franceschini et al. (2021), Creptotrema is a monophyletic genus of trematodes widely distributed across the Americas, which currently comprises 19 valid species of parasites of teleost fish and anurans.
123Travassos L, Artigas P, Pereira C. 1928. Fauna helminthologica dos peixes de agua doce do Brasil. Archivos do Instituto Biológico de Defesa Agricola e Animal, 1, 5–68.