DIP2A

DIP2A

Identifiers

DIP2A, C21orf106, DIP2, disco interacting protein 2 homolog A

External IDs

OMIM: 607711; MGI: 2385920; GeneCards: DIP2A

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
6.2.1.1	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 21 (human)

Band	21q22.3	Start	46,458,891 bp
Band	21q22.3	End	46,570,015 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10 C1\|10 38.76 cM	Start	76,095,263 bp
Band	10 C1\|10 38.76 cM	End	76,181,125 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

visceral pleura

parietal pleura

tibia

cardia

ventral tegmental area

renal medulla

inferior ganglion of vagus nerve

nipple

sperm

endothelial cell

Top expressed in

substantia nigra

deep cerebellar nuclei

otolith organ

utricle

iris

anterior horn of spinal cord

nucleus of stria terminalis

trigeminal ganglion

pontine nuclei

central gray substance of midbrain

More reference expression data


More reference expression data

Gene ontology
Molecular function	catalytic activity protein binding
Cellular component	nucleus cell surface
Biological process	multicellular organism development negative regulation of gene expression metabolism regulation of apoptotic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23181


64451


ENSG00000160305


ENSMUSG00000020231


Q14689


Q8BWT5

RefSeq (mRNA)

NM_001146114 NM_001146115 NM_001146116 NM_015151 NM_206889
NM_206890 NM_206891 NM_001353942 NM_001353943 NM_001353944


NM_001081419

RefSeq (protein)

NP_001139587 NP_001139588 NP_055966 NP_996772 NP_996773
NP_996774 NP_001340871 NP_001340872 NP_001340873


NP_001074888

Location (UCSC)

Chr 21: 46.46 – 46.57 Mb

Chr 10: 76.1 – 76.18 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Disco-interacting protein 2 homolog A is a protein that in humans is encoded by the DIP2A gene.

See also

DIP2B
DIP2C

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160305 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020231 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)".

Further reading

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Mukhopadhyay M, Pelka P, DeSousa D, et al. (2002). "Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog". Gene. 293 (1–2): 59–65. doi:10.1016/S0378-1119(02)00694-7. PMID 12137943.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Casadei R, Strippoli P, D'Addabbo P, et al. (2004). "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs". Gene. 321: 185–93. doi:10.1016/S0378-1119(03)00835-7. hdl:11586/196824. PMID 14637006.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Winnepenninckx B, Debacker K, Ramsay J, et al. (2007). "CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1". Am. J. Hum. Genet. 80 (2): 221–31. doi:10.1086/510800. PMC 1785358. PMID 17236128.

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