DPM1

DPM1
Identifiers
Aliases	DPM1, CDGIE, MPDS, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, dolichyl-phosphate mannosyltransferase subunit 1, catalytic
External IDs	OMIM: 603503; MGI: 1330239; GeneCards: DPM1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 20 (human)
End	50,959,140 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	168,072,511 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; germinal epithelium; ; sperm; ; Skeletal muscle tissue of biceps brachii; ; oral cavity; ; skin of hip; ; gums; ; gingival epithelium; ; amniotic fluid; ; mucosa of pharynx;
	Top expressed in
	spermatocyte; ; spermatid; ; yolk sac; ; morula; ; blastocyst; ; right kidney; ; muscle of thigh; ; neural layer of retina; ; embryo; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; dolichyl-phosphate beta-D-mannosyltransferase activity; protein binding; dolichyl-phosphate-mannose-protein mannosyltransferase activity;
Cellular component	endoplasmic reticulum membrane; membrane; endoplasmic reticulum; dolichol-phosphate-mannose synthase complex; nucleus;
Biological process	protein O-linked mannosylation; protein N-linked glycosylation via asparagine; protein glycosylation; GPI anchor biosynthetic process; protein mannosylation; dolichol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8813
	13480
	ENSG00000000419
	ENSMUSG00000078919
	O60762
	O70152
	NM_003859; NM_001317034; NM_001317035; NM_001317036
	NM_010072; NM_001310084
	NP_001303963; NP_001303964; NP_001303965; NP_003850
	NP_001297013; NP_034202
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the DPM1 gene.

Function

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000000419 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078919 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Colussi PA, Taron CH, Mack JC, Orlean P (Jul 1997). "Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe". Proceedings of the National Academy of Sciences of the United States of America. 94 (15): 7873–8. Bibcode:1997PNAS...94.7873C. doi:10.1073/pnas.94.15.7873. PMC 21522. PMID 9223280.
↑ Tomita S, Inoue N, Maeda Y, Ohishi K, Takeda J, Kinoshita T (Apr 1998). "A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells". The Journal of Biological Chemistry. 273 (15): 9249–54. doi:10.1074/jbc.273.15.9249. PMID 9535917.
1 2 "Entrez Gene: DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit".

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000000419 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078919 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9223280-5] Colussi PA, Taron CH, Mack JC, Orlean P (Jul 1997). "Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe". Proceedings of the National Academy of Sciences of the United States of America. 94 (15): 7873–8. Bibcode:1997PNAS...94.7873C. doi:10.1073/pnas.94.15.7873. PMC 21522. PMID 9223280.

[pmid9535917-6] Tomita S, Inoue N, Maeda Y, Ohishi K, Takeda J, Kinoshita T (Apr 1998). "A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells". The Journal of Biological Chemistry. 273 (15): 9249–54. doi:10.1074/jbc.273.15.9249. PMID 9535917.

[entrez-7] 1 2 "Entrez Gene: DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit".

DPM1

Function

References

Further reading

External links