Born in João Ramalho, São Paulo, Guedes joined Santos FC's youth setup in 2011, aged 17. On 19 February 2014 he renewed his link with Peixe until 2017.
On 30 November 2014, Guedes made his first team – and Série A – debut, starting in a 2–0 home win against Botafogo. He established himself as a starter under new head coach Marcelo Fernandes in the following year, as the starting right-back Victor Ferraz was regularly used in the other flank.
On 22 September 2015, Guedes further extended his contract until February 2019. Mainly a backup option to Victor Ferraz, he scored his first professional goal on 12 July 2017, netting from a direct free kick in a 1–0 away win against Atlético Mineiro.
On 18 July 2017, Guedes renewed his contract until June 2022. He began the 2018 campaign as a starter under new head coach Jair Ventura, but subsequently lost his starting spot to longtime incumbent Victor Ferraz.
Goiás (loan)
On 12 March 2019, after being demoted to third-choice after the return Matheus Ribeiro, Guedes was loaned to fellow top tier side Goiás until the end of the year. He initially split his starting spot with Yago Rocha, but was preventively suspended in September after being caught in a doping exam.
Guedes was sentenced an eight-month ban on 16 July 2020, but since he already had spent ten months without playing, his sentence was already served. He was later able to prove that the contamination came from a soursop juice.
Cruzeiro (loan)
On 8 August 2020, Guedes was loaned to Série B side Cruzeiro until December 2021. He left the club in November, after just seven matches, and attempted to return to Goiás on loan until the end of the campaign; he only stayed at the club for two weeks, as the loan was subsequently declared void after Goiás failed to reach an agreement with Santos.
Back to the Raposa, Guedes was separated from the first team squad by new head coach Luiz Felipe Scolari.
Upon returning, Guedes was not registered by Peixe for the 2022 Campeonato Paulista, and terminated his contract with the club on 24 March 2022.
Cuiabá
On 9 April 2022, Guedes signed for Cuiabá also in the top tier. He featured in 14 league matches as his side narrowly avoided relegation.
Later career
On 12 December 2022, Guedes was announced at Juventude in the second division. After leaving the club at the end of the 2023 season, he spent nearly a year without a club before signing for Paraná on 26 November 2024.
On 30 November 2025, Guedes was confirmed as Juventus-SP's new signing for the upcoming campaign.
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