Dichlorophen

Dichlorophen
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	P02DX02 (WHO) ;
Identifiers
	IUPAC name 4-Chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol;
CAS Number	97-23-4 ;
PubChem CID	3037;
ChemSpider	2929 ;
UNII	T1J0JOU64O;
KEGG	C14292 ;
ChEMBL	ChEMBL33845 ;
CompTox Dashboard (EPA)	DTXSID6021824 ;
ECHA InfoCard	100.002.335
Chemical and physical data
Formula	C13H10Cl2O2
Molar mass	269.12 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.5 g/cm3 g/cm3
Melting point	177.5 °C (351.5 °F)
Solubility in water	0.003 g/100 mL mg/mL (20 °C)
	SMILES C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O;
	InChI InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2 ; Key:MDNWOSOZYLHTCG-UHFFFAOYSA-N ;
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Dichlorophen is an organochlorine compound with the formula CH₂(C₆H₃(OH)Cl)₂. In terms of molecular structure, it consists of two 4-chlorophenol groups linked by a methylene.

It is anticestodal agent, fungicide, germicide, and antimicrobial agent. It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats. In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.

Safety and regulation

The LD₅₀ (oral, mouse) is 3300 mg/kg.

References

↑ Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.
1 2 Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.
↑ Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books
↑ "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01
↑ Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.

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[hand2-1] Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.

[a-2] 1 2 Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.

[gard-3] Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books

[cfr-4] "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01

[5] Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.