Didier Pittet (born 20 March 1957 in Geneva, Switzerland) is a Swiss infectious diseases expert and the director of the Infection Control Programme and WHO Collaborating Centre on Patient Safety, University Hospital of Geneva, Geneva, Switzerland. Since 2005, Pittet is also the External Lead of the World Health Organization (WHO) Global Patient Safety Challenge "Clean Care is Safer Care" and African Partnerships for Patient Safety.
In the 2007 New Year Honours List, Didier Pittet was awarded the Honorary Commander of the Order of the British Empire (CBE) in recognition of his services related to the prevention of healthcare-associated infections in the UK.
Career
Pittet graduated in 1976 from the Collège Calvin secondary school in Geneva, Switzerland. Following a Diploma in Tropical Medicine and Community Health at the University of Geneva Faculty of Medicine, he graduated as M.D. in 1983 from the same institution, and received a master's degree (MS) in Epidemiology and Public Health from the University of Iowa, Iowa City, US, in 1992. Pittet began his career as an infectious diseases expert with a special interest in the intensive care setting and device-associated and yeast infections, but this rapidly expanded to include research in overall hospital epidemiology and infection prevention and control. In 1992, he was appointed as Director of the Infection Control Programme at the University Hospital of Geneva and named Professor of Medicine in 2000 by the University of Geneva Faculty of Medicine.
Academic and other posts (selected)
Pittet is visiting professor, Division of Investigative Science and School of Medicine, Imperial College London, London, UK; Honorary Professor, 1st Medical School of the Fu, Shanghai, China; Honorary Professor, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
Since 2002, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Planning Committee member Since 2011, Co-chair, 1st International Conference on Prevention and Infection Control (ICPIC)
Landmark research
Initial observation studies in Geneva by Pittet's team showed a low compliance with basic hand hygiene practices and a lack of awareness by healthcare workers that the main cause of cross-transmission of microorganisms is by hands. Time constraint was identified as the major determinant for poor compliance. The challenge was to facilitate hand hygiene for staff and to find an innovative idea to do so. Under Pittet's leadership, the team investigated concepts from the social sciences to help understand the determinants driving healthcare worker behaviour, which led to the creation of a multimodal strategy based on education, recognition of opportunities for hand hygiene, and feedback on performance where the key component was the introduction of alcohol-based hand rub at the point of care to replace handwashing at the sink ("system change"), thus bypassing the time constraint of the latter method.
"The Geneva Hand Hygiene Model": a breakthrough intervention
The first multimodal intervention ran from 1995 to 2000 at the University of Geneva Hospitals with a spectacular decrease of almost 50% in hospital-associated infections and methicillin-resistant Staphylococcus aureus (MRSA) transmission in parallel with a sustained improvement in compliance with hand hygiene. The methodology and results were published in The Lancet in 2000 and the strategy became known in as "The Geneva Hand Hygiene Model". During 1995–1997, Pittet had applied the same multimodal concept to a prevention strategy targeted at vascular access care and showed that it can decrease these infections and substantially impact on the overall incidence of all intensive care unit-acquired infections. Similarly, interventions to reduce urinary tract infections were successfully applied. Pittet's team also proved the cost-effectiveness of their interventions and long-term sustainability.
Going global
In 2004, Pittet was approached by the WHO World Alliance of Patient Safety to lead the First Global Patient Safety Challenge under the banner "Clean Care is Safer Care". The mandate was to galvanise global commitment to tackle health-care associated infection, which had been identified as a significant area of risk for patients in all United Nations Member States. Hand hygiene was to be the cornerstone of the Challenge. As co-author of the United States Centers for Disease Control and Prevention (CDC) Guidelines for Hand Hygiene, Pittet proposed that WHO Guidelines for Hand Hygiene in Health Care be developed under his leadership in consultation with other international experts. The final version of the Guidelines was published in 2009. In 2008, the infection control programme of the University of Geneva Hospitals and Faculty of Medicine was designated as the first WHO Collaborating Centre for Patient Safety (Infection Control and Improving Practices) in Europe.
The "Geneva Hand Hygiene Model" was used as the basis for the recommended implementation strategy for the global promotion of hand hygiene. As of December 2011, "Clean Care is Safer Care" has been endorsed by ministers of health in over 120 countries worldwide―representing a coverage of more than 90% of the world population. Forty-two countries/networks have already started hand hygiene initiatives using the proposed strategy. Alcohol-based hand rub is promoted actively as the new standard of care, including in resource-poor countries. Pittet's team developed the "Five Moments" concept to explain to healthcare workers the critical moments when hand hygiene must be carried out and this model is currently used worldwide. Save Lives: Clean Your Hands is the Challenge's annual campaign with almost 15,000 hospitals registered from more than 150 countries at the end of December 2011.
Selected awards and honours
1999: 1st Ignaz Philipp Semmelweis Research Prize (accomplishments in the field of hand hygiene)
1999: The Hygiene Prize 1999 - Rudolf Schülke Foundation (accomplishments in the field of infection control)
2002: Society of Health Care Epidemiology of America (SHEA) Young Investigator Award in recognition of outstanding career contributions to infection control and healthcare epidemiology
2003: The Lowbury Lecture, Federation of Infection Societies Annual Conference (UK)
2005: The Graham Ayliffe Lecture (Hospital Infection Society), UK
2007: Honorary Commander of the Order of the British Empire (CBE)
2008: Society for Healthcare Epidemiology of America (SHEA) Lectureship
2008: Forbes Fellow, Melbourne Infectious Diseases Group (Australia)
2009: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Award for Excellence in Clinical Microbiology and Infectious Diseases
Hand hygiene dance video based on the "My five moments for hand hygiene" concept. "Ô les mains", VigiGerme, Infection Control Programme, University of Geneva Hospitals. 2010.
Pittet is author/co-author of approximately 500 publications, including 300 peer-reviewed publications and 50 chapters in authoritative medical textbooks.
Pittet, D; Hugonnet, S; Harbarth, S; Mourouga, P; Sauvan, V; Touveneau, S; Perneger, TV (2000). "Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme". The Lancet. 356 (9238): 1307–12. doi:10.1016/S0140-6736(00)02814-2. PMID11073019. S2CID18760147.
Eggimann, P; Harbarth, S; Constantin, MN; Touveneau, S; Chevrolet, JC; Pittet, D (2000). "Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care". The Lancet. 355 (9218): 1864–8. doi:10.1016/S0140-6736(00)02291-1. PMID10866442. S2CID35022749.
Pittet, D; Simon, A; Hugonnet, S; Pessoa-Silva, CL; Sauvan, V; Perneger, TV (2004). "Hand hygiene among physicians: Performance, beliefs, and perceptions". Annals of Internal Medicine. 141 (1): 1–8. doi:10.7326/0003-4819-141-1-200407060-00008. PMID15238364. S2CID2654346.
Pittet D, Harbarth S. The intensive care unit. In: Hospital Infections. Brachman PS and Bennett JV, eds, 5th ed. Lippincott Williams & Wilkins, Philadelphia; 2007.
Pittet D, Allegranzi B, Sax H. Hand hygiene. In: Hospital Infections. Brachman PS and Bennett JV, eds, 5th ed. Lippincott Williams & Wilkins, Philadelphia; 2007.
Allegranzi B, Longtin Y, Pittet D. Infection control in the healthcare setting. In: Control of Communicable Diseases Manual. Heymann DL (ed), 19th ed. American Public Health Association, Washington, DC, USA. 2008.
Sax H, Pittet D. Severe soft-tissue infections. In: Oh's Manual for Intensive Care Medicine. Bersten A, Sony N, Oh T, eds. 6th ed. Butterworth-Heinemann (Elsevier Ltd), London, UK, chap 63, pp 731–737, 2009.
Baratti-Mayer, D; Pittet, B; Montandon, D (2004). "GESNOMA (Geneva Study Group on Noma): State-of-the-art medical research for humanitarian purposes". Annales de Chirurgie Plastique et Esthétique. 49 (3): 302–5. doi:10.1016/j.anplas.2004.04.005. PMID15276261.
Haustein, T; Gastmeier, P; Holmes, A; Lucet, JC; Shannon, RP; Pittet, D; Harbarth, S (2011). "Use of benchmarking and public reporting for infection control in four high-income countries". The Lancet Infectious Diseases. 11 (6): 471–81. doi:10.1016/S1473-3099(10)70315-7. PMID21616457.
Pittet, Didier; Boyce, John M (2001). "Hand hygiene and patient care: Pursuing the Semmelweis legacy". The Lancet Infectious Diseases. 1 (1): 9–10. doi:10.1016/S1473-3099(09)70295-6.
Stewardson, A; Allegranzi, B; Sax, H; Kilpatrick, C; Pittet, D (2011). "Back to the future: Rising to the Semmelweis challenge in hand hygiene". Future Microbiology. 6 (8): 855–76. doi:10.2217/FMB.11.66. PMID21861619.
Pittet, D; Allegranzi, B; Sax, H; Dharan, S; Pessoa-Silva, CL; Donaldson, L; Boyce, JM; Who Global Patient Safety Challenge, World Alliance for Patient Safety (2006). "Evidence-based model for hand transmission during patient care and the role of improved practices". The Lancet Infectious Diseases. 6 (10): 641–52. doi:10.1016/S1473-3099(06)70600-4. PMID17008173.
Pittet, D; Allegranzi, B; Sax, H; Chraiti, MN; Griffiths, W; Richet, H; World Health Organization Global Patient Safety Challenge Alcohol-Based Handrub Task Force (2007). "Double-blind, randomized, crossover trial of 3 hand rub formulations: Fast-track evaluation of tolerability and acceptability". Infection Control and Hospital Epidemiology. 28 (12): 1344–51. doi:10.1086/523272. PMID17994514. S2CID33987958.
Widmer, AF; Rotter, M; Voss, A; Nthumba, P; Allegranzi, B; Boyce, J; Pittet, D (2010). "Surgical hand preparation: State-of-the-art". The Journal of Hospital Infection. 74 (2): 112–22. doi:10.1016/j.jhin.2009.06.020. PMID19716627.
Hand hygiene guidelines
Boyce, JM; Pittet, D; Healthcare Infection Control Practices Advisory Committee; HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force (2002). "Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America". MMWR. Recommendations and Reports. 51 (RR–16): 1–45, quiz CE1–4. PMID12418624.
Sax, H; Allegranzi, B; Chraïti, MN; Boyce, J; Larson, E; Pittet, D (2009). "The World Health Organization hand hygiene observation method". American Journal of Infection Control. 37 (10): 827–34. doi:10.1016/j.ajic.2009.07.003. PMID20004812.
Pittet, D.; Panesar, S.S.; Wilson, K.; Longtin, Y.; Morris, T.; Allan, V.; Storr, J.; Cleary, K.; Donaldson, L. (2011). "Involving the patient to ask about hospital hand hygiene: A National Patient Safety Agency feasibility study". Journal of Hospital Infection. 77 (4): 299–303. doi:10.1016/j.jhin.2010.10.013. PMID21236515.
Multimodal interventions to reduce infections
Pittet, Didier; Hugonnet, Stéphane; Harbarth, Stephan; Mourouga, Philippe; Sauvan, Valérie; Touveneau, Sylvie; Perneger, Thomas V (2000). "Effectiveness of a hospital-wide programme to improve compliance with hand hygiene". The Lancet. 356 (9238): 1307–12. doi:10.1016/S0140-6736(00)02814-2. PMID11073019. S2CID18760147.
Eggimann, P; Harbarth, S; Constantin, MN; Touveneau, S; Chevrolet, JC; Pittet, D (2000). "Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care". The Lancet. 355 (9218): 1864–8. doi:10.1016/S0140-6736(00)02291-1. PMID10866442. S2CID35022749.
Pessoa-Silva, C. L.; Hugonnet, S.; Pfister, R.; Touveneau, S.; Dharan, S.; Posfay-Barbe, K.; Pittet, D. (2007). "Reduction of Health Care Associated Infection Risk in Neonates by Successful Hand Hygiene Promotion". Pediatrics. 120 (2): e382–90. doi:10.1542/peds.2006-3712. PMID17664257. S2CID7745276.
Pittet, D.; Tarara, D.; Wenzel, R. P. (1994). "Nosocomial Bloodstream Infection in Critically III Patients: Excess Length of Stay, Extra Costs, and Attributable Mortality". JAMA: The Journal of the American Medical Association. 271 (20): 1598–601. doi:10.1001/jama.1994.03510440058033. PMID8182812.
Pittet, D; Wenzel, RP (1995). "Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths". Archives of Internal Medicine. 155 (11): 1177–84. doi:10.1001/archinte.1995.00430110089009. PMID7763123.
Hugonnet, Stéphane; Harbarth, Stephan; Ferrière, Karin; Ricou, Bara; Suter, Peter; Pittet, Didier (2003). "Bacteremic sepsis in intensive care: Temporal trends in incidence, organ dysfunction, and prognosis". Critical Care Medicine. 31 (2): 390–4. doi:10.1097/01.CCM.0000045026.81584.6F. PMID12576941. S2CID22326570.
Catheter-associated infections
Widmer, A. F.; Pittet, D. (1992). "Optimal Duration of Therapy for Catheter-Related Staphylococcus aureus Bacteremia". Clinical Infectious Diseases. 14 (6): 1259–60. doi:10.1093/clinids/14.6.1259. PMID1623083.
Eggimann, P; Harbarth, S; Constantin, MN; Touveneau, S; Chevrolet, JC; Pittet, D (2000). "Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care". The Lancet. 355 (9218): 1864–8. doi:10.1016/S0140-6736(00)02291-1. PMID10866442. S2CID35022749.
Eggimann, P; Hugonnet, S; Sax, H; Harbarth, S; Chevrolet, JC; Pittet, D (2005). "Long-term reduction of vascular access-associated bloodstream infection". Annals of Internal Medicine. 142 (10): 875–6. doi:10.7326/0003-4819-142-10-200505170-00025. PMID15897546.
Zingg, W.; Sax, H.; Inan, C.; Cartier, V.; Diby, M.; Clergue, F.; Pittet, D.; Walder, B. (2009). "Hospital-wide surveillance of catheter-related bloodstream infection: From the expected to the unexpected". Journal of Hospital Infection. 73 (1): 41–6. doi:10.1016/j.jhin.2009.05.015. PMID19646788.
Perencevich, E. N.; Pittet, D. (2009). "Preventing Catheter-Related Bloodstream Infections: Thinking Outside the Checklist". JAMA: The Journal of the American Medical Association. 301 (12): 1285–7. doi:10.1001/jama.2009.420. PMID19318658.
Pittet, Didier; Bonten, Marc JM (2000). "Towards invasive diagnostic techniques as standard management of ventilator-associated pneumonia". The Lancet. 356 (9233): 874. doi:10.1016/S0140-6736(00)02675-1. PMID11036890. S2CID3088752.
Pittet, D; Eggimann, P; Rubinovitch, B (2001). "Prevention of ventilator-associated pneumonia by oral decontamination: Just another SDD study?". American Journal of Respiratory and Critical Care Medicine. 164 (3): 338–9. doi:10.1164/ajrccm.164.3.2105072b. PMID11500329.
Pittet, D; Zingg, W (2010). "Reducing ventilator-associated pneumonia: When process control allows outcome improvement and even benchmarking". Critical Care Medicine. 38 (3): 983–4. doi:10.1097/CCM.0b013e3181c8fd0c. PMID20168154.
Harbarth, S; Holeckova, K; Froidevaux, C; Pittet, D; Ricou, B; Grau, GE; Vadas, L; Pugin, J; Geneva Sepsis, Network (2001). "Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis". American Journal of Respiratory and Critical Care Medicine. 164 (3): 396–402. doi:10.1164/ajrccm.164.3.2009052. PMID11500339.
Hugonnet, S; Eggimann, P; Sax, H; Touveneau, S; Chevrolet, JC; Pittet, D (2002). "Intensive care unit-acquired infections: Is postdischarge surveillance useful?". Critical Care Medicine. 30 (12): 2636–8. doi:10.1097/00003246-200212000-00004. PMID12483051. S2CID44340854.
Rangel-Frausto, M. S.; Pittet, D.; Costigan, M.; Hwang, T.; Davis, C. S.; Wenzel, R. P. (1995). "The Natural History of the Systemic Inflammatory Response Syndrome (SIRS) A Prospective Study". JAMA: The Journal of the American Medical Association. 273 (2): 117–23. doi:10.1001/jama.1995.03520260039030. PMID7799491.
Eggimann, P; Garbino, J; Pittet, D (2003). "Epidemiology of Candida species infections in critically ill non-immunosuppressed patients". The Lancet Infectious Diseases. 3 (11): 685–702. doi:10.1016/S1473-3099(03)00801-6. PMID14592598.
Eggimann, P; Garbino, J; Pittet, D (2003). "Management of Candida species infections in critically ill patients". The Lancet Infectious Diseases. 3 (12): 772–85. doi:10.1016/S1473-3099(03)00831-4. PMID14652203.
Epidemiology of Methicillin-resistant Staphylococcus aureus
Harbarth, S; Sax, H; Fankhauser-Rodriguez, C; Schrenzel, J; Agostinho, A; Pittet, D (2006). "Evaluating the probability of previously unknown carriage of MRSA at hospital admission". The American Journal of Medicine. 119 (3): 275.e15–23. doi:10.1016/j.amjmed.2005.04.042. PMID16490475.
Pessoa-Silva, CL; Hugonnet, S; Pfister, R; Touveneau, S; Dharan, S; Posfay-Barbe, K; Pittet, D (2007). "Reduction of health care associated infection risk in neonates by successful hand hygiene promotion". Pediatrics. 120 (2): e382–90. doi:10.1542/peds.2006-3712. PMID17664257. S2CID7745276.
Posfay-Barbe, KM; Zerr, DM; Pittet, D (2008). "Infection control in paediatrics". The Lancet Infectious Diseases. 8 (1): 19–31. doi:10.1016/S1473-3099(07)70310-9. PMID18156087.
12Pittet, D; Hugonnet, S; Harbarth, S; Mourouga, P; Sauvan, V; Touveneau, S; Perneger, TV (2000). "Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme". The Lancet. 356 (9238): 1307–12. doi:10.1016/S0140-6736(00)02814-2. PMID11073019. S2CID18760147.
↑Eggimann, P; Harbarth, S; Constantin, MN; Touveneau, S; Chevrolet, JC; Pittet, D (2000). "Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care". The Lancet. 355 (9218): 1864–8. doi:10.1016/S0140-6736(00)02291-1. PMID10866442. S2CID35022749.