EGF-binding protein type B
| Kallikrein 13 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.119 | ||||||||
| CAS no. | 342900-44-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
EGF-binding protein type B (EC 3.4.21.119) also called mouse Kallikrein 13 (mK13) is an enzyme found specifically in the submandibular (saliva) glands of mice, and encoded by the gene Egfbp2. This enzyme catalyses hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin.
This enzyme belongs in peptidase family S1A. Its closest relative in humans is predicted to be kallikrein-1.
Other names
It has also been called Kallikrein 13 (ambiguous), KLK13 (ambiguous), kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P
References
- ↑ Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K (December 1990). "Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis". The Journal of Biological Chemistry. 265 (34): 21027–31. doi:10.1016/S0021-9258(17)45322-1. PMID 2250008.
- ↑ Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K (April 1990). "A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization". The Journal of Biological Chemistry. 265 (11): 5930–3. doi:10.1016/S0021-9258(19)39267-1. PMID 2180937.
- ↑ Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K (January 1998). "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1382 (1): 55–64. doi:10.1016/s0167-4838(97)00144-1. PMID 9507064.
- ↑ Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K (March 2006). "Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice". The Journal of Biological Chemistry. 281 (12): 7968–76. doi:10.1074/jbc.m507705200. PMID 16423834.
- ↑ "P36368 · EGFB2_MOUSE". UniProt consortium. Retrieved 2026-10-21.
External links
- Kallikrein+13 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
