EMSY Protein-coding gene in the species Homo sapiens
EMSY is a protein that in humans is encoded by the EMSY gene .
Clinical significance
EMSY has been shown to associate with atopy and susceptibility to poly-sensitisation.
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000158636 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035401 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Entrez Gene: C11orf30 chromosome 11 open reading frame 30" .↑ Amaral AF, Minelli C, Guerra S, Wjst M, Probst-Hensch N, Pin I, et al. (March 2015). "The locus C11orf30 increases susceptibility to poly-sensitization". Allergy . 70 (3): 328– 333. doi :10.1111/all.12557 . hdl :10044/1/21574 PMID 25546184 . S2CID 25960081 . 1 2 3 Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, et al. (November 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer" . Cell . 115 (5): 523– 535. doi :10.1016/S0092-8674(03)00930-9 PMID 14651845 . S2CID 18911371 .
Further reading
Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, et al. (2004). "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate" . Proceedings of the National Academy of Sciences of the United States of America . 101 (9): 3059– 3064. Bibcode :2004PNAS..101.3059B . doi :10.1073/pnas.0308746101 PMC 365744 PMID 14981236 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130– 12135. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, et al. (2005). "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69" . EMBO Reports . 6 (7): 675– 680. doi :10.1038/sj.embor.7400415 . PMC 1369107 PMID 15947784 . Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, et al. (2005). "Crystal structure of the ENT domain of human EMSY". Journal of Molecular Biology . 350 (5): 964– 973. doi :10.1016/j.jmb.2005.05.047 . PMID 15978617 . Benusiglio PR, Lesueur F, Luccarini C, McIntosh J, Luben RN, Smith P, et al. (2005). "Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs" . BMC Cancer . 5 81. doi :10.1186/1471-2407-5-81 PMC 1185523 PMID 16029503 . Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, et al. (2005). "Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY" . Journal of the National Cancer Institute . 97 (17): 1302– 1306. doi :10.1093/jnci/dji254 PMID 16145051 . Brown LA, Irving J, Parker R, Kim H, Press JZ, Longacre TA, et al. (2006). "Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas". Gynecologic Oncology . 100 (2): 264– 270. doi :10.1016/j.ygyno.2005.08.026 . PMID 16236351 . Huang Y, Myers MP, Xu RM (2006). "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding" . Structure . 14 (4). London: 703– 712. doi :10.1016/j.str.2006.01.007 PMID 16615912 .
PDB gallery
1utu : CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY TRUNCATE
1uz3 : CRYSTAL STRUCTURE OF NOVEL PROTEIN EMSY
2fmm : Crystal Structure of EMSY-HP1 complex
