Datlow began her career working for Holt, Rinehart and Winston for three years, as well as doing a stint at Crown Publishing Group. She went on to be fiction editor at Omni magazine and Omni Online from 1981 through 1998, and edited the ten associated Omni anthologies. She co-edited the Year's Best Fantasy and Horror series from 1988 to 2008 (with Terri Windling until 2003, later with Gavin Grant and Kelly Link until the series ended). She was also editor of the webzine Event Horizon: Science Fiction, Fantasy, and Horror from 1998 to 1999, as well as Sci Fiction until it ceased publication on December 28, 2005.
Datlow has edited the anthologies Nebula Awards Showcase 2009, Darkness: Two Decades of Horror (2010), Hauntings (2013), Queen Victoria's Book of Spells (with Terri Windling, Tor Books, 2013), Lovecraft's Monsters (2014), The Cutting Room (2014), The Monstrous (2015), Nightmares (Tachyon Publications, 2016), The Doll Collection (2016), Mad Hatters and March Hares (2017), The Devil and the Deep (2018), Echoes: The Saga Anthology of Ghost Stories (2019), When Things Get Dark (2021), and Night & Day: Dreadful Dark/Merciless Sun (2025).
In 1992, Gahan Wilson wrote in an issue of Weird Tales that "Datlow is, book by book, magazine by magazine, showing herself to be one of those rare editors who, like Anthony Boucher, say, or Judith Merril, now and then enter this field and quietly change it from top to bottom for the better."
In 2011, Datlow received the Lifetime Achievement Award by the Horror Writers Association. She has been a trustee of the Horror Writers Association since 2006 and a co-host of the Fantastic Fiction reading series at the KGB bar in New York City since 2000.
Selected list of awards
1989 World Fantasy Award for Best Anthology, The Year's Best Fantasy: First Annual Collection (with Terri Windling)
1990 World Fantasy Award for Best Anthology, The Year's Best Fantasy: Second Annual Collection (with Terri Windling)
1992 World Fantasy Award for Best Anthology, The Year's Best Fantasy and Horror: Fourth Annual Collection (with Terri Windling)
1995 World Fantasy Award for Best Anthology, Little Deaths
1995 World Fantasy Special Award, professional
2000 World Fantasy Award for Best Anthology, Silver Birch, Blood Moon (with Terri Windling)
2003 World Fantasy Award for Best Anthology, The Green Man (with Terri Windling)
2007 World Fantasy Award for Best Anthology, Salon Fantastique (with Terri Windling)
2008 World Fantasy Award for Best Anthology, Inferno
↑"About Us". Fantastic Fiction at KGB. Retrieved July 2, 2025.
↑"Candidates' Statements & Platforms". Horror Writers Association. September 1, 2006. Archived from the original on July 2, 2025. Retrieved July 2, 2025.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
↑"Contact HWA". Horror Writers Association. October 1, 2006. Archived from the original on October 3, 2006. Retrieved July 2, 2025.
↑"Females of Fright: Ellen Datlow". Horror Writers Association. February 12, 2020. Archived from the original on September 16, 2021. Retrieved July 2, 2025.{{cite web}}: CS1 maint: bot: original URL status unknown (link)