FEM-1689

FEM-1689
Identifiers
  • 3-[5-[4-(trifluoromethyl)phenyl]-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-9-yl]propan-1-ol
CAS Number
PubChem CID
Chemical and physical data
FormulaC21H22F3NO
Molar mass361.408 g·mol−1
3D model (JSmol)
  • FC(F)(F)c1ccc(cc1)c1cc2c(cc1)C1CC2N(CC1)CCCO
  • InChI=1S/C21H22F3NO/c22-21(23,24)17-5-2-14(3-6-17)15-4-7-18-16-8-10-25(9-1-11-26)20(13-16)19(18)12-15/h2-7,12,16,20,26H,1,8-11,13H2
  • Key:DYYGKMZHHOOCGT-UHFFFAOYSA-N

FEM-1689 is a drug which acts as a potent and selective sigma-2 receptor ligand with a binding affinity of 11 nM, and was developed for the treatment of neuropathic pain.

References

  1. ↑ Yousuf MS, Sahn JJ, Yang H, David ET, Shiers S, Mancilla Moreno M, et al. (December 2023). "Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response". Proceedings of the National Academy of Sciences of the United States of America. 120 (52) e2306090120. Bibcode:2023PNAS..12006090Y. doi:10.1073/pnas.2306090120. PMC 10756276. PMID 38117854.