PB-28

PB-28
PB28
PB28
Names
IUPAC name
1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra- hydronaphthalen-1-yl)propyl]piperazine
Other names
PB28
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.215.826 Edit this at Wikidata
MeSH C097775
UNII
  • InChI=1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3 X markN
    Key: PHRCDWVPTULQMT-UHFFFAOYSA-N X markN
  • InChI=1/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3
    Key: PHRCDWVPTULQMT-UHFFFAOYAW
  • COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1
Properties
C24H38N2O
Molar mass 370.57 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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PB-28 is an agonist of the sigma-2 receptor.

It is derived from cyclohexylpiperazine.

Usage

Research and oncology

In oncology, it has been noted that PB-28 reverts doxorubicin resistance of breast cancer cells by supplementing Oxygen (O
2) receptor binding.