GL64

GL64
Identifiers
  • 3-(4-chlorophenyl)-2-[3-[(2,4-dichlorophenyl)methoxy]phenyl]-1,2-dihydroquinazolin-4-one
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC27H19Cl3N2O2
Molar mass509.81 g·mol−1
3D model (JSmol)
  • C1=CC=C2C(=C1)C(=O)N(C(N2)C3=CC(=CC=C3)OCC4=C(C=C(C=C4)Cl)Cl)C5=CC=C(C=C5)Cl
  • InChI=1S/C27H19Cl3N2O2/c28-19-10-12-21(13-11-19)32-26(31-25-7-2-1-6-23(25)27(32)33)17-4-3-5-22(14-17)34-16-18-8-9-20(29)15-24(18)30/h1-15,26,31H,16H2
  • Key:OPKSEEXRWAXFIK-UHFFFAOYSA-N

GL64 is a chemical compound which acts as an agonist at the androgen receptor GPR133. It increases bone density by inhibiting osteoclastogenesis, and shows beneficial effects in an animal model of osteoporosis.

See also

References

  1. ↑ He L, Zhang Q, You Y, Sun P, Xu Z, Li R, et al. (July 2025). "Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis". Science Advances. 11 (28) eads3829. doi:10.1126/sciadv.ads3829. PMC 12248284. PMID 40644539.