Adhesion G protein-coupled receptor D1 is a protein that in humans is encoded by the ADGRD1gene (previously GPR133).
This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
ADGRD1 binds androgens, specifically the androgen 5α-dihydrotestosterone (5α-DHT). ADGRD1 is an adhesion G protein-coupled receptor that functions as a membrane receptor for androgens. When activated by 5α-DHT, ADGRD1 increases intracellular cyclic AMP (cAMP) levels in muscle cells, leading to enhanced muscle strength.
Agonists of ADGRD1 such as GL64 and AP503 have potential applications in the treatment of osteoporosis.
↑Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN978-1-4419-7912-4.
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Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID15203201.
