GPR179

GPR179
Identifiers
Aliases	GPR179, CSNB1E, GPR158L, GPR158L1, G protein-coupled receptor 179
External IDs	OMIM: 614515; MGI: 2443409; GeneCards: GPR179
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,343,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,242,903 bp
RNA expression pattern
	Top expressed in
	testicle; ; prefrontal cortex; ; superior frontal gyrus; ; sural nerve; ; primary visual cortex; ; Brodmann area 9; ; skeletal muscle tissue; ; hypothalamus; ; right frontal lobe; ; nucleus accumbens;
	Top expressed in
	neural layer of retina; ; vestibular sensory epithelium; ; epithelium of lens; ; hypothalamus; ; left ventricle; ; diencephalic nucleus; ; aortic valve; ; nucleus of hypothalamus; ; adrenal gland; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; visual perception; response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	440435
	217143
	ENSG00000276469; ENSG00000277399
	ENSMUSG00000070337
	Q6PRD1
	E9PY61
	NM_001004334
	NM_001081220; NM_175453
	NP_001004334
	NP_001074689
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 179 is a protein that in humans is encoded by the GPR179 gene.

Clinical relevance

Mutations in this gene have been associated to cases of congenital stationary Night Blindness.

1 2 3 ENSG00000277399 GRCh38: Ensembl release 89: ENSG00000276469, ENSG00000277399 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070337 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GPR179 G protein-coupled receptor 179".
↑ Audo I, Bujakowska K, Orhan E, Poloschek CM, Defoort-Dhellemmes S, Drumare I, Kohl S, Luu TD, Lecompte O, Zrenner E, Lancelot ME, Antonio A, Germain A, Michiels C, Audier C, Letexier M, Saraiva JP, Leroy BP, Munier FL, Mohand-Saïd S, Lorenz B, Friedburg C, Preising M, Kellner U, Renner AB, Moskova-Doumanova V, Berger W, Wissinger B, Hamel CP, Schorderet DF, De Baere E, Sharon D, Banin E, Jacobson SG, Bonneau D, Zanlonghi X, Le Meur G, Casteels I, Koenekoop R, Long VW, Meire F, Prescott K, de Ravel T, Simmons I, Nguyen H, Dollfus H, Poch O, Léveillard T, Nguyen-Ba-Charvet K, Sahel JA, Bhattacharya SS, Zeitz C (Feb 10, 2012). "Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness". American Journal of Human Genetics. 90 (2): 321–30. doi:10.1016/j.ajhg.2011.12.007. PMC 3276675. PMID 22325361.