GPR146

GPR146
Identifiers
Aliases	GPR146, PGR8, G protein-coupled receptor 146
External IDs	MGI: 1933113; GeneCards: GPR146
Gene location (Human)
Chr.	Chromosome 7 (human)
End	1,059,261 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,396,415 bp
RNA expression pattern
	Top expressed in
	subcutaneous adipose tissue; ; abdominal fat; ; apex of heart; ; gastric mucosa; ; right lung; ; tibial nerve; ; blood; ; left ventricle; ; body of stomach; ; upper lobe of left lung;
	Top expressed in
	interventricular septum; ; retinal pigment epithelium; ; muscle of thigh; ; myocardium of ventricle; ; left lobe of liver; ; right lung; ; triceps brachii muscle; ; right kidney; ; right lung lobe; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	115330
	80290
	ENSG00000164849
	ENSMUSG00000044197
	Q96CH1
	Q99LE2
	NM_001303473; NM_001303474; NM_138445
	NM_001038703; NM_030258
	NP_001290402; NP_001290403; NP_612454
	NP_001033792; NP_084534; NP_001349135
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions. GPR146 has also been identified as a possible receptor for C-peptide.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164849 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044197 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GPR146 G protein-coupled receptor 146".
↑ Hu X, Chen F, Jia L, Long A, Peng Y, Li X; et al. (2024). "A gut-derived hormone regulates cholesterol metabolism". Cell. 187 (7): 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. PMID 38503280.{{cite journal}}: CS1 maint: multiple names: authors list (link)
↑ Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F; et al. (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis". Cell. 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMC 6889877. PMID 31778654. Archived from the original on September 27, 2024.{{cite journal}}: CS1 maint: multiple names: authors list (link)
↑ Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi:10.1530/JOE-13-0203. PMID 23759446.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164849 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044197 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR146 G protein-coupled receptor 146".

[pmid38503280-6] Hu X, Chen F, Jia L, Long A, Peng Y, Li X; et al. (2024). "A gut-derived hormone regulates cholesterol metabolism". Cell. 187 (7): 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. PMID 38503280.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid31778654-7] Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F; et al. (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis". Cell. 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMC 6889877. PMID 31778654. Archived from the original on September 27, 2024.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[8] Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi:10.1530/JOE-13-0203. PMID 23759446.

GPR146

References

Further reading