GPR68

GPR68

Identifiers

GPR68, GPR12A, OGR1, G protein-coupled receptor 68, AI2A6

External IDs

OMIM: 601404; MGI: 2441763; GeneCards: GPR68

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q32.11	Start	91,232,532 bp
Band	14q32.11	End	91,253,925 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12\|12 E	Start	100,842,941 bp
Band	12\|12 E	End	100,874,457 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

granulocyte

gingival epithelium

testicle

cardia

pylorus

buccal mucosa cell

saphenous vein

pituitary gland

human penis

Top expressed in

zygote

oocyte

primary oocyte

secondary oocyte

mesenteric lymph nodes

lumbar subsegment of spinal cord

dentate gyrus of hippocampal formation granule cell

cerebellar cortex

hippocampus proper

ciliary body

More reference expression data


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	G protein-coupled receptor signaling pathway negative regulation of monocyte differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus cellular response to pH inflammatory response positive regulation of osteoclast development signal transduction positive regulation of insulin secretion
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8111


238377


ENSG00000119714


ENSMUSG00000047415


Q15743


Q8BFQ3

RefSeq (mRNA)


NM_001177676 NM_003485 NM_001348437


NM_001177673 NM_001177674 NM_175493

RefSeq (protein)


NP_001171147 NP_003476 NP_001335366


NP_001171144 NP_001171145 NP_780702 NP_001390243

Location (UCSC)

Chr 14: 91.23 – 91.25 Mb

Chr 12: 100.84 – 100.87 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.

See also

Proton-sensing G protein-coupled receptors

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119714 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047415 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
↑ "Entrez Gene: GPR68 G protein-coupled receptor 68".

Further reading

Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1–3): 81–8. doi:10.1016/S1388-1981(02)00140-3. PMID 12069813.
An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. S2CID 9845527.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. Bibcode:2003Natur.425...93L. doi:10.1038/nature01905. PMID 12955148. S2CID 4395698.
Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. Bibcode:2005PNAS..102.1632R. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.
Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi:10.1074/jbc.M505287200. PMID 16087674.
Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi:10.1093/jnci/djm107. hdl:10536/DRO/DU:30094039. PMID 17728215.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 A B D α2 A B C β1 β2 β3
Purinergic	Adenosine A1 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14
Serotonin	(all but 5-HT3) 5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7
Other	Acetylcholine M1 M2 M3 M4 M5 Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin 1A 1B 1C TAAR 1 2 5 6 8 9

Metabolites and
signaling molecules

Eicosanoid	CysLT 1 2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free fatty acid 1 2 3 4 Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid 1 2 3 4 5 6 Lysophospholipid 1 2 3 4 5 6 7 8 Oxoglutarate PAF Sphingosine-1-phosphate 1 2 3 4 5 Succinate

Peptide

Chemokine	ACKR 1 2 3 4 5 CCR 1 2 L2 3 4 5 6 7 8 9 10 CX3CR1 CXC 1 2 3 4 5 6 XCR1
Neuropeptide	B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2
Other	Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin 1 2 Cholecystokinin A B Endothelin A B Formyl peptide 1 2 3 FSH Galanin 1 2 3 Gonadotropin-releasing hormone 1 2 Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS 1 1L D E F G X1 X2 X3 X4 Melanocortin 1 2 3 4 5 MCHR 1 2 Motilin Opioid Delta Kappa Mu Nociceptin and Zeta, but not Sigma Orexin 1 2 Oxytocin Prokineticin 1 2 Prolactin-releasing peptide Relaxin 1 2 3 4 Somatostatin 1 2 3 4 5 Tachykinin 1 2 3 Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin 1A 1B 2

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR 3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 143 146 148 149 150 151 152 153 157 160 161 162 171 173 174 176 177 183
Other	Olfactory Opsin 3 4 5 1LW 1MW 1SW RGR RRH Protease-activated 1 2 3 4 SREB 1 2 3

Class B: Secretin-like

Secretin subfamily (B1)	Calcitonin CALCRL Corticotropin-releasing hormone 1 2 Glucagon GR GIPR GLP1R GLP2R Growth-hormone-releasing hormone PACAPR1 Parathyroid hormone 1 2 Secretin Vasoactive intestinal peptide 1 2
Adhesion (B2)	ADGRA 1 2 3 ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRD 1 2 ADGRE EMR 1 2 3 CD97 ADGRF 1 2P 3 4 5 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 4 ADGRV1 GPR155
Methuselah-like proteins (B3)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B 1 2 Glutamate receptor Metabotropic glutamate 1 2 3 4 5 6 7 8 GPRC6A GPR 156 158 179 RAIG 1 2 3 4

Class F: Frizzled and Smoothened

Frizzled	Frizzled 1 2 3 4 5 6 7 8 9 10
Smoothened	Smoothened
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