GPR12

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752; MGI: 101909; GeneCards: GPR12
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,760,786 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,522,049 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; Region I of hippocampus proper; ; dorsal striatum; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylcholine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; cellular calcium ion homeostasis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941; NM_008151; NM_001359055; NM_001359056; NM_001359057;
	NM_001359058
	NP_005279
NP_001010941; NP_032177; NP_001345984; NP_001345985; NP_001345986;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.

Ligands

Inverse agonists

Cannabidiol

Evolution

Paralogues

Source:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
↑ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
↑ "Entrez Gene: GPR12 G protein-coupled receptor 12".
↑ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
↑ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
↑ "GeneCards®: The Human Gene Database".

GPR12

Ligands

Evolution

Paralogues

References

Further reading