GPR6

GPR6
Identifiers
Aliases	GPR6, G protein-coupled receptor 6
External IDs	OMIM: 600553; MGI: 2155249; GeneCards: GPR6
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,980,720 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	40,948,281 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; putamen; ; caudate nucleus; ; middle frontal gyrus; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; external globus pallidus; ; pituitary gland; ; entorhinal cortex;
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; nucleus accumbens; ; globus pallidus; ; superior frontal gyrus; ; temporal lobe; ; amygdala; ; mammillary body; ; ventromedial nucleus; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; sphingosine-1-phosphate receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2830
	140741
	ENSG00000146360
	ENSMUSG00000046922
	P46095
	Q6YNI2
	NM_005284; NM_001286099
	NM_199058
	NP_001273028; NP_005275
	NP_951013
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active. It was previously thought to also act as a sphingosine-1-phosphate receptor, but this was found to not be the case in later research.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Ligand

Inverse Agonist

Cannabidiol
Solangepras (solengepras; CVN-424)

Evolution

Paralogues to GPR6 gene

Source:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GPR6 G protein-coupled receptor 6".
↑ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–953. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
↑ "G protein-coupled receptor 6". UniProt consortium. Retrieved 2026-09-26.
↑ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–10515. doi:10.1074/jbc.M700911200. PMID 17284443.
↑ Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol". Acta Pharmacologica Sinica. 40 (3): 300–308. doi:10.1038/s41401-018-0031-9. PMC 6460361. PMID 29941868.
↑ "GeneCards®: The Human Gene Database".

External links

"GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-02. Retrieved 2009-04-24.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR6 G protein-coupled receptor 6".

[pmid8530049-6] Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.

[pmid12220620-7] Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–953. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.

[8] "G protein-coupled receptor 6". UniProt consortium. Retrieved 2026-09-26.

[pmid17284443-9] Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–10515. doi:10.1074/jbc.M700911200. PMID 17284443.

[10] Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol". Acta Pharmacologica Sinica. 40 (3): 300–308. doi:10.1038/s41401-018-0031-9. PMC 6460361. PMID 29941868.

[11] "GeneCards®: The Human Gene Database".