GPR161

GPR161
Identifiers
AliasesGPR161, RE2, G protein-coupled receptor 161
External IDsOMIM: 612250; MGI: 2685054; GeneCards: GPR161
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

23432

240888

Ensembl

ENSG00000143147

ENSMUSG00000040836

UniProt

Q8N6U8

B2RPY5

RefSeq (mRNA)

NM_001081126
NM_001310429
NM_001310430

RefSeq (protein)

NP_001074595
NP_001297358
NP_001297359

Location (UCSC)Chr 1: 168.08 – 168.14 MbChr 1: 165.12 – 165.15 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene. It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143147 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040836 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Small KM, Seman CA, Castator A, Brown KM, Liggett SB (Apr 2002). "False positive non-synonymous polymorphisms of G-protein coupled receptor genes". FEBS Letters. 516 (1–3): 253–256. Bibcode:2002FEBSL.516..253S. doi:10.1016/S0014-5793(02)02564-4. PMID 11959142. S2CID 35944696.
  6. ↑ "Entrez Gene: GPR161 G protein-coupled receptor 161".
  7. ↑ Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E (2020). "Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium". Cells. 9 (1): 118. doi:10.3390/cells9010118. PMC 7017137. PMID 31947770.
  8. ↑ Patel K, Smith NJ (2024). "Primary cilia, A-kinase anchoring proteins and constitutive activity at the orphan G protein-coupled receptor GPR161: A tale about a tail". British Journal of Pharmacology. 181 (14): 2182–2196. doi:10.1111/bph.16053. PMID 36772847.
  9. ↑ Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, et al. (2024). "GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway". Nature Structural & Molecular Biology. 31 (4): 667–677. doi:10.1038/s41594-024-01223-8. PMC 11221913. PMID 38326651.
  10. ↑ Paillard T, Allam A, Doulazmi M, Hautefeuille M, Fouquet C, Sarde L, et al. (2025). "GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration". Science Advances. 11 (31) eadx3846. doi:10.1126/sciadv.adx3846. PMC 12309678. PMID 40737401.

Further reading

  • Schöneberg T, Schulz A, Gudermann T (2002). "The structural basis of G-protein-coupled receptor function and dysfunction in human diseases". Reviews of Physiology, Biochemistry and Pharmacology. Vol. 144. pp. 143–227. doi:10.1007/BFb0116587. ISBN 978-3-540-42814-5. PMID 11987825.
  • Raming K, Konzelmann S, Breer H (1999). "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone". Receptors & Channels. 6 (2): 141–151. PMID 9932290.