GTF3C4

GTF3C4

Identifiers

GTF3C4, KAT12, TFIII90, TFIIIC290, TFIIIC90, TFIIICDELTA, TF3C-delta, general transcription factor IIIC subunit 4

External IDs

OMIM: 604892; MGI: 2138937; GeneCards: GTF3C4

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.1.48	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q34.13	Start	132,670,035 bp
Band	9q34.13	End	132,694,953 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 A3	Start	28,822,299 bp
Band	2\|2 A3	End	28,840,360 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

gonad

ventricular zone

gingival epithelium

islet of Langerhans

ganglionic eminence

testicle

hair follicle

stromal cell of endometrium

middle temporal gyrus

skin of thigh

Top expressed in

ureter

medullary collecting duct

saccule

otic placode

vas deferens

renal corpuscle

otic vesicle

fossa

condyle

vestibular sensory epithelium

More reference expression data


More reference expression data

Gene ontology
Molecular function	histone acetyltransferase activity transferase activity DNA binding enzyme activator activity acyltransferase activity protein binding
Cellular component	transcription factor TFIIIC complex nucleoplasm nucleus mitochondrion
Biological process	tRNA transcription by RNA polymerase III 5S class rRNA transcription by RNA polymerase III transcription initiation from RNA polymerase III promoter transcription, DNA-templated positive regulation of catalytic activity transcription by RNA polymerase III histone acetylation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9329


269252


ENSG00000125484


ENSMUSG00000035666


Q9UKN8


Q8BMQ2

RefSeq (mRNA)


NM_012204


NM_001166033 NM_172977

RefSeq (protein)


NP_036336


NP_001159505 NP_766565

Location (UCSC)

Chr 9: 132.67 – 132.69 Mb

Chr 2: 28.82 – 28.84 Mb

PubMed search

View/Edit Human

View/Edit Mouse

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.

Interactions

GTF3C4 has been shown to interact with GTF3C2, GTF3C1, POLR3C and GTF3C5.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125484 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035666 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
↑ "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
↑ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading

Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.

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