POLR3C

POLR3C

Identifiers

POLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82

External IDs

OMIM: 617454; MGI: 1921664; GeneCards: POLR3C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2XUB, 2XV4, 5AFQ

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q21.1	Start	145,824,088 bp
Band	1q21.1	End	145,844,402 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3\|3 F2.1	Start	96,618,806 bp
Band	3\|3 F2.1	End	96,634,944 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

gonad

Achilles tendon

stromal cell of endometrium

monocyte

left testis

right testis

canal of the cervix

granulocyte

gallbladder

right ovary

Top expressed in

otic vesicle

intestinal villus

yolk sac

mesenteric lymph nodes

granulocyte

epiblast

seminiferous tubule

ventricular zone

jejunum

ileum

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity DNA binding protein binding RNA polymerase III activity single-stranded DNA binding
Cellular component	RNA polymerase III complex cytosol nucleoplasm nucleus
Biological process	positive regulation of interferon-beta production regulation of transcription by RNA polymerase III defense response to virus transcription, DNA-templated positive regulation of innate immune response immune system process innate immune response transcription by RNA polymerase III positive regulation of type I interferon production
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10623


74414


ENSG00000186141


ENSMUSG00000028099


Q9BUI4


Q9D483

RefSeq (mRNA)


NM_001303456 NM_006468


NM_028925

RefSeq (protein)


NP_001290385 NP_006459


NP_083201

Location (UCSC)

Chr 1: 145.82 – 145.84 Mb

Chr 3: 96.62 – 96.63 Mb

PubMed search

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.

Interactions

POLR3C has been shown to interact with GTF3C4.

Related gene problems

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186141 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028099 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
↑ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
↑ "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
↑ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
↑ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
↑ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". American Journal of Human Genetics. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
Kuwana M, Kimura K, Kawakami Y (October 2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis and Rheumatism. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.

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