HEPPS (buffer)

HEPPS
HEPPS
HEPPS
Names
Preferred IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
HEPPS, EPPS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.036.528 Edit this at Wikidata
UNII
  • InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) checkY
    Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N checkY
  • InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
    Key: OWXMKDGYPWMGEB-UHFFFAOYAP
  • O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
C9H20N2O4S
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkYX markN ?)

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.

See also

References

  1. ↑ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.
  2. ↑ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015.
  3. ↑ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. Bibcode:2015NatCo...6.8997K. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
  4. ↑ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.
  5. ↑ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4) eaav1388. Bibcode:2019SciA....5.1388K. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMC 6469948. PMID 31001580.
  6. ↑ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined". Analysis & Separations from Technology Networks. Retrieved 2019-09-30.
  7. ↑ "A possible blood test for early-stage Alzheimer's disease". medicalxpress.com. Retrieved 2019-09-30.