HLA-DR8

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
human major histocompatibility complex, class II, DR8
Haplotypes groups DQA*01:DRB1*0801 to

DQA*01:DRB1*0806

Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA[permanent dead link]
EBI-HLA DRA*0101
Identifiers
beta 1 *0801 to *0806
Symbol(s) HLA-DRB1[permanent dead link]
EBI-HLA DRB1*0801
EBI-HLA DRB1*0802
EBI-HLA DRB1*0803
EBI-HLA DRB1*0804
EBI-HLA DRB1*0805
EBI-HLA DRB1*0806
Shared data
Locus chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

DR8 serological recognition of the gene products of some DRB1*08 alleles
DRB1*DR8 Sample
allele%size (N)
0801951076
080296265
080388230
080493186
0805>605
0806>7513

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DR8 is linked to papillary thyroid carcinomas, early onset pauciarticular juvenile chronic arthritis, primary biliary cirrhosis

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis In Mexicans DR8 is found more often in type-2 juvenile diabetes.

HLA-DRB1*0803 is also linked to primary biliary cirrhosis

Genetic Linkage

DR8 Haplotypes
DRADRB1
Haplotypes *0101*0801*0101
DQA1DQB1DRB1
Haplotypes *0401*0402*0801
HLA-AHLA-BDRB1
Haplotypes *0000*0000*0801

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ DR12 - 3%
  3. ↑ Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas". Clin Endocrinol. 64 (2): 179–83. doi:10.1111/j.1365-2265.2006.02445.x. PMID 16430717. S2CID 22695710.
  4. ↑ Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E (1994). "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis". Clin Exp Rheumatol. 12 (Suppl 10): S7–14. PMID 7955632.
  5. ↑ Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population". J Rheumatol. 31 (11): 2281–5. PMID 15517645.
  6. ↑ Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype". Hepatology. 16 (6): 1404–8. doi:10.1002/hep.1840160616. PMID 1359995. S2CID 7200339.
  7. 1 2 Charatcharoenwitthaya P, Lindor K (2005). "Current concepts in the pathogenesis of primary biliary cirrhosis". Ann Hepatol. 4 (3): 161–75. doi:10.1016/S1665-2681(19)32061-7. PMID 16177655.
  8. ↑ Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al. (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric Diabetes. 8 (1): 5–10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285. S2CID 35352151.