Dr. Jung Se-ok, a brilliant but disgraced neurosurgeon, is haunted by a past tragedy. Stripped of her medical license, she resorts to performing illegal surgeries in the shadows, driven by an insatiable thirst for pushing the boundaries of neuroscience. When her path crosses with her former mentor, the renowned but enigmatic Dr. Choi Deok-hee, old wounds are reopened and a dangerous game of power and revenge ensues. As Se-ok delves deeper into groundbreaking yet ethically questionable procedures, she grapples with the moral consequences of her actions, blurring the lines between medical necessity and personal ambition.
Writer Kim Sun-hee, who wrote Quiz of God: Reboot (2018), and director Kim Jung-hyun, who directed Awaken (2021–2022) and Crazy Love (2022), teamed up for the series. CJENM Studios, Dongpung Co., Ltd. and Blaad Studios managed the production.
Casting
In 2023, Sul Kyung-gu and Park Eun-bin were both considering appearing for the series. In 2024, both Yoon Chan-young and Park Byung-eun reportedly received an offer to appear alongside Sul and Park. On April 3, the four actors were officially confirmed to play various roles in the series.
On August 12, 2024, Disney+ announced that Hyper Knife would be released in the first half of 2025. On January 7, 2025, Disney+ confirmed the release date of the series to be on March 19, after unveiling the lineup of the platform's original Korean dramas for 2025.
↑하이퍼 나이프 OST[Hyper Knife OST]. Bugs (in Korean). Universal Music Group. Hollywood Records. April 8, 2025. Retrieved April 8, 2025.
1234Park, Jung-sun (April 3, 2024). 설경구·박은빈·박병은·윤찬영, '하이퍼 나이프' 출연 확정[Sul Kyung-gu, Park Eun-bin, Park Byung-eun, and Yoon Chan-young confirmed to appear in 'Hyper Knife']. JTBC (in Korean). Archived from the original on July 15, 2024. Retrieved January 8, 2025.
12Shin, Young-eun (April 3, 2024). 설경구X박은빈 '하이퍼 나이프'서 만난다...촬영 돌입[Seol Kyung-gu X Park Eun-bin meet in 'Hyper Knife'...Filming begins]. MK (in Korean). Retrieved January 8, 2025.
↑Ha, Soo-jeong. 설경구 "박은빈이 이런 역할을 하다니..출연한 큰 이유"(하이퍼나이프)[Seol Kyung-gu "Park Eun-bin plays this kind of role... A big reason for appearing" (Hyperknife)]. OSEN (in Korean). Archived from the original on February 26, 2025. Retrieved March 6, 2025– via Naver.
↑Hwang, So-young (November 22, 2023). [단독] 설경구, 드라마 '하이퍼 나이프' 주인공[[Exclusive] Sul Kyung-gu, the main character of the drama 'Hyper Knife']. JTBC (in Korean). Archived from the original on July 15, 2024. Retrieved January 8, 2025.
↑Choi, Hee-jae (December 6, 2023). 박은빈, 이번엔 사이코 의사?..."'하이퍼 나이프' 출연 검토 중"[Park Eun-bin, a psycho doctor this time?..."Considering appearance in 'Hyper Knife'"]. Edaily (in Korean). Retrieved January 8, 2025.
↑Park, Jung-sun (March 8, 2024). [단독] '지우학' 윤찬영, 설경구·박은빈 주연 '하이퍼 나이프' 출연 물망[[Exclusive] Yoon Chan-young of 'AoUAD', a candidate to appear in 'Hyper Knife' starring Sul Kyung-gu and Park Eun-bin]. JTBC (in Korean). Archived from the original on July 15, 2024. Retrieved January 8, 2025.
↑Kang, Hyo-jin (March 11, 2024). [단독]박병은, 박은빈·설경구 만날까...기대작 '하이퍼나이프' 합류[[Exclusive] Will Park Byung-eun meet Park Eun-bin and Sul Kyung-gu? Joining the highly anticipated 'Hyperknife']. SPOTV News (in Korean). Archived from the original on July 15, 2024. Retrieved January 8, 2025.
↑Kang, Hyo-jin (August 12, 2024). 박은빈X설경구 '하이퍼 나이프', 2025년 상반기 디즈니+ 공개[공식][Park Eun-bin X Sul Kyung-gu 'Hyper Knife', Disney+ Release in the First Half of 2025 [Official]]. SPOTV News (in Korean). Archived from the original on January 19, 2025. Retrieved January 7, 2025.
↑강, 보라 (August 12, 2025). "아이유 '폭싹 속았수다'→김태리 '정년이'...벡델데이, 양성평등 시리즈 10편 선정"[IU's I Was Totally Fooled → Kim Tae-ri's Jeongnyeoni... Bechdel Day selects 10 gender-equality series]. Single List (in Korean). Archived from the original on August 13, 2025. Retrieved August 12, 2025.
↑이, 미지 (22 July 2025). 박보검·주지훈·박보영·아이유, 2025 글로벌OTT어워즈 주연상 노미네이트[Park Bo-gum, Joo Ji-hoon, Park Bo-young, and IU were nominated for the 2025 Global OTT Awards]. Pop Herald (in Korean). Retrieved 2025-07-22.