INSL5

INSL5
Identifiers
Aliases	INSL5, PRO182, UNQ156, insulin like 5
External IDs	OMIM: 606413; MGI: 1346085; GeneCards: INSL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K1V, 2KBC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	66,801,276 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	102,884,039 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of sigmoid colon; ; testicle; ; mucosa of transverse colon; ; right uterine tube; ; hypothalamus; ; Brodmann area 9; ; nucleus accumbens; ; hippocampus proper; ; muscle tissue;
	Top expressed in
	left colon; ; neural layer of retina; ; epithelium of small intestine; ; thymus; ; embryo; ; embryo; ; spermatid; ; inner nuclear layer; ; enteric nervous system; ; outer nuclear layer;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; G protein-coupled receptor binding;
Cellular component	extracellular region; cellular component;
Biological process	positive regulation of feeding behavior; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10022
	23919
	ENSG00000172410
	ENSMUSG00000066090
	Q9Y5Q6
	Q9WUG6
	NM_005478
	NM_001290648; NM_011831
	NP_005469
	NP_001277577; NP_035961
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like peptide 5 (INSL5) is a hormone that in humans is encoded by the INSL5 gene. This hormone is secreted by the large intestines and activates the RXFP4 receptor with high affinity. It may be involved in regulating intestinal contractions or the development of the thymus.

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin-3 (RLN3/INSL7).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172410 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066090 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S (August 1999). "Identification of INSL5, a new member of the insulin superfamily". Genomics. 60 (1): 50–6. doi:10.1006/geno.1999.5899. PMID 10458910.
1 2 "Entrez Gene: INSL5 insulin-like 5".
1 2 "Insulin-like peptide INSL5". UniProt consortium. Retrieved 2026-10-24.

External links

INSL5 human gene location in the UCSC Genome Browser.
INSL5 human gene details in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9Y5Q6 (Human Insulin-like peptide INSL5) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172410 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066090 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10458910-5] Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S (August 1999). "Identification of INSL5, a new member of the insulin superfamily". Genomics. 60 (1): 50–6. doi:10.1006/geno.1999.5899. PMID 10458910.

[entrez-6] 1 2 "Entrez Gene: INSL5 insulin-like 5".

[uniprot-7] 1 2 "Insulin-like peptide INSL5". UniProt consortium. Retrieved 2026-10-24.

INSL5

Function

References

Further reading

External links