Relaxin/insulin-like family peptide receptor 4

RXFP4
Identifiers
Aliases	RXFP4, GPCR142, GPR100, RLN3R2, RXFPR4, Relaxin/insulin-like family peptide receptor 4, relaxin/insulin like family peptide receptor 4, relaxin family peptide/INSL5 receptor 4
External IDs	OMIM: 609043; MGI: 2182926; GeneCards: RXFP4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,943,087 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,560,449 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; sural nerve; ; rectum; ; granulocyte; ; duodenum; ; monocyte; ; bone marrow; ; blood; ; appendix; ; gastric mucosa;
	Top expressed in
	embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; signal transducer activity; galanin receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of feeding behavior; signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	339403
	242093
	ENSG00000173080
	ENSMUSG00000049741
	Q8TDU9
	Q7TQP4
	NM_181885
	NM_181817
	NP_871001
	NP_861538
	Wikidata
View/Edit Human	View/Edit Mouse

Relaxin/insulin-like family peptide receptor 4 (RXFP4), also called RLN3 receptor 2, is a protein that in humans is encoded by the gene RXFP4. It is expressed especially in the intestines, where it acts as a high affinity receptor for the hormone INSL5, and can also be activated by RLN3, bradykinin, and kallidin.

RXFP4 is specifically a G-protein coupled receptor (rhodopsin-like family) which couples to a G_io-family G-proteins, and so activation reduces cellular cAMP levels.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173080 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049741 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".
1 2 "Relaxin-3 receptor 2". UniProt consortium. Retrieved 2026-10-24.

External links

"Relaxin Family Peptide Receptors: RXFP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173080 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049741 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4".

[uniprot-6] 1 2 "Relaxin-3 receptor 2". UniProt consortium. Retrieved 2026-10-24.

Relaxin/insulin-like family peptide receptor 4

See also

References

Further reading

External links