KDM4D

KDM4D
Identifiers
Aliases	KDM4D, JMJD2D, lysine demethylase 4D
External IDs	OMIM: 609766; MGI: 3606484; GeneCards: KDM4D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,999,519 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,411,778 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left testis; ; right testis; ; testicle; ; gonad; ; sperm; ; secondary oocyte; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; lumbar spinal ganglion; ; embryo; ; lumbar subsegment of spinal cord; ; facial motor nucleus; ; primary visual cortex; ; superior frontal gyrus; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; histone H3-methyl-lysine-9 demethylase activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; damaged DNA binding; chromatin DNA binding; methylated histone binding;
Cellular component	blood microparticle; nucleus; nucleoplasm; site of double-strand break; pericentric heterochromatin; histone methyltransferase complex;
Biological process	regulation of protein phosphorylation; cellular response to ionizing radiation; regulation of transcription, DNA-templated; positive regulation of chromatin binding; double-strand break repair via homologous recombination; transcription, DNA-templated; positive regulation of double-strand break repair via nonhomologous end joining; histone H3-K9 demethylation; negative regulation of transcription by RNA polymerase II; chromatin organization; cellular response to DNA damage stimulus; negative regulation of histone H3-K9 trimethylation; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55693
	244694
	ENSG00000186280
	ENSMUSG00000053914
	Q6B0I6
	Q3U2K5
	NM_018039
	NM_173433
	NP_060509
	NP_775609
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene. KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material. A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186280 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053914 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
↑ "Entrez Gene: JMJD2D jumonji domain containing 2D".
↑ Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
↑ Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
↑ Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4): dev158261. doi:10.1242/dev.158261. PMID 29453221.

v t e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate	Prolyl hydroxylase HIF prolyl-hydroxylase EGLN1 EGLN2 EGLN3 P4HTM Lysyl hydroxylase AlkB ALKBH1 FTO
1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 14α-demethylase 24-hydroxycholesterol 7α-hydroxylase
1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1
1.14.15: reduced iron–sulfur protein	11B1 11B2 11A1
1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase
1.14.17: reduced ascorbate	Dopamine beta-hydroxylase
1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2 Ecdysone 20-monooxygenase Deoxyhypusine monooxygenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

KDM4D

References

Further reading