Knebel is a German surname of multiple origins. Notable people with the surname include:
- Andreas Knebel (born 1960), East German athlete
- Corey Knebel (born 1991), American professional baseball player
- Fletcher Knebel (1911–1993), American author of several popular works of political fiction
- Gottfried Knebel (born 1908), German botanist
- John A. Knebel (born 1936), United States Secretary of Agriculture 1976–1977
- Joseph Knebel (1854–1926), Russian publisher
- Karl Ludwig von Knebel (1744–1834), German poet and translator
- Maren Knebel, German sprint canoeist who has competed since the mid-2000s
- Maria Knebel (1898–1985), Russian actor, director, and teacher
