LIN7C

LIN7C

Identifiers

LIN7C, LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, lin-7 homolog C, crumbs cell polarity complex component

External IDs

OMIM: 612332; MGI: 1330839; GeneCards: LIN7C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3LRA

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p14.1	Start	27,494,418 bp
Band	11p14.1	End	27,506,769 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2 E3\|2 56.65 cM	Start	109,721,198 bp
Band	2 E3\|2 56.65 cM	End	109,731,348 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Epithelium of choroid plexus

germinal epithelium

epithelium of nasopharynx

retinal pigment epithelium

tibia

oral cavity

Brodmann area 23

visceral pleura

parietal pleura

kidney tubule

Top expressed in

olfactory epithelium

lobe of cerebellum

medial ganglionic eminence

median eminence

pineal gland

cerebellar vermis

zygote

tail of embryo

dentate gyrus

superior cervical ganglion

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein domain specific binding cytoskeletal protein binding L27 domain binding PDZ domain binding
Cellular component	cytoplasm postsynaptic membrane postsynaptic density membrane cell-cell junction bicellular tight junction plasma membrane MPP7-DLG1-LIN7 complex cell junction basolateral plasma membrane neuron projection presynapse synapse glutamatergic synapse
Biological process	protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport morphogenesis of an epithelial sheet neurotransmitter secretion exocytosis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55327


22343


ENSG00000148943


ENSMUSG00000027162


Q9NUP9


O88952

RefSeq (mRNA)


NM_018362


NM_011699

RefSeq (protein)


NP_060832


NP_035829

Location (UCSC)

Chr 11: 27.49 – 27.51 Mb

Chr 2: 109.72 – 109.73 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.

Interactions

LIN7C has been shown to interact with:

DLG1,
KCNJ12, and
KCNJ4.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148943 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027162 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
↑ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".
1 2 3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
1 2 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011. PMID 12006486.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. Bibcode:2003FEBSL.554...30H. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi:10.1074/jbc.M506536200. PMID 16147993.
Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi:10.1074/jbc.M506623200. PMID 16192275.
Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma" (PDF). Cancer Res. 67 (20): 9643–8. doi:10.1158/0008-5472.CAN-07-1911. hdl:10130/633. PMID 17942893.

v t e PDB gallery
2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B

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