KCNJ12

KCNJ12
Identifiers
Aliases	KCNJ12, IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, potassium voltage-gated channel subfamily J member 12, potassium inwardly rectifying channel subfamily J member 12
External IDs	OMIM: 602323; MGI: 108495; GeneCards: KCNJ12
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2 Start 21,376,357 bp End 21,419,870 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B2|11 37.96 cM Start 60,913,390 bp End 60,961,957 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis cerebellar vermis muscle of thigh cerebellar hemisphere right hemisphere of cerebellum gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle Skeletal muscle tissue of biceps brachii Top expressed in muscle of thigh cerebellar cortex lumbar spinal ganglion sternocleidomastoid muscle lens triceps brachii muscle skeletal muscle tissue knee joint temporal muscle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inward rectifier potassium channel activity voltage-gated ion channel activity G-protein activated inward rectifier potassium channel activity protein binding Cellular component integral component of membrane intrinsic component of membrane plasma membrane integral component of plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport muscle contraction regulation of heart contraction protein homotetramerization ion transport potassium ion import across plasma membrane cardiac conduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3768 16515 Ensembl ENSG00000184185 ENSMUSG00000042529 UniProt Q14500 P52187 RefSeq (mRNA) NM_021012 NM_001267593 NM_010603 RefSeq (protein) NP_066292 NP_001254522 NP_034733 Location (UCSC) Chr 17: 21.38 – 21.42 Mb Chr 11: 60.91 – 60.96 Mb PubMed search
Wikidata
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ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.

Function

This gene encodes an inwardly rectifying K⁺ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith–Magenis syndrome region on chromosome 17.

Interactions

KCNJ12 has been shown to interact with:

See also

• Inward-rectifier potassium channel