GJD2

GJD2
Identifiers
Aliases	GJD2, CX36, GJA9, gap junction protein delta 2
External IDs	OMIM: 607058; MGI: 1334209; GeneCards: GJD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N6A
Gene location (Human)
Chr.	Chromosome 15 (human)
End	34,754,998 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	113,844,100 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gonad; ; pituitary gland; ; anterior pituitary; ; prefrontal cortex; ; right auricle of heart; ; body of pancreas; ; occipital lobe; ; dorsolateral prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	thoracic ganglia; ; islet of Langerhans; ; neural layer of retina; ; lumbar subsegment of spinal cord; ; stellate ganglion; ; anterior horn of spinal cord; ; facial motor nucleus; ; pineal gland; ; olfactory bulb; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	gap junction channel activity;
Cellular component	integral component of membrane; gap junction; cell junction; plasma membrane; connexin complex; membrane;
Biological process	action potential; cell communication; cell-cell signaling; visual perception; chemical synaptic transmission; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57369
	14617
	ENSG00000159248
	ENSMUSG00000068615
	Q9UKL4
	O54851
	NM_020660
	NM_010290
	NP_065711
	NP_034420
	Wikidata
View/Edit Human	View/Edit Mouse

Gap junction delta-2 protein (GJD2), also known as connexin-36 (Cx36) or gap junction alpha-9 protein (GJA9), is a protein that in humans is encoded by the GJD2 gene.

Function

GJD2, also called connexin-36 (CX36), is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Connexins associate in groups of 6 and are organized radially around a central pore to form connexons. Each gap junction intercellular channel is formed by the conjunction of 2 connexons. See GJB2 for additional background information on connexins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159248 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068615 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Belluardo N, Trovato-Salinaro A, Mudo G, Hurd YL, Condorelli DF (Oct 1999). "Structure, chromosomal localization, and brain expression of human Cx36 gene". J Neurosci Res. 57 (5): 740–52. doi:10.1002/(SICI)1097-4547(19990901)57:5<740::AID-JNR16>3.0.CO;2-Z. PMID 10462698. S2CID 496510.
1 2 "Entrez Gene: GJA9 gap junction protein, alpha 9, 36kDa".

External links

Overview of all the structural information available in the PDB for UniProt: Q9UKL4 (Gap junction delta-2 protein) at the PDBe-KB.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159248 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068615 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10462698-5] Belluardo N, Trovato-Salinaro A, Mudo G, Hurd YL, Condorelli DF (Oct 1999). "Structure, chromosomal localization, and brain expression of human Cx36 gene". J Neurosci Res. 57 (5): 740–52. doi:10.1002/(SICI)1097-4547(19990901)57:5<740::AID-JNR16>3.0.CO;2-Z. PMID 10462698. S2CID 496510.

[entrez-6] 1 2 "Entrez Gene: GJA9 gap junction protein, alpha 9, 36kDa".

GJD2

Function

References

Further reading

External links