LSN2463359

LSN2463359
Names
	IUPAC name N-Propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide
Identifiers
CAS Number	1401031-52-4 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2431212;
ChemSpider	30835751.html : 30835751;
EC Number	802-759-0;
IUPHAR/BPS	6394;
PubChem CID	72551298;
CompTox Dashboard (EPA)	DTXSID601166641 ;
	InChI InChI=1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20) Key: STAFRSGTRKNXHF-UHFFFAOYSA-N;
	SMILES CC(C)NC(=O)C1=NC=C(C=C1)C#CC2=CC=NC=C2;
Properties
Chemical formula	C16H15N3O
Molar mass	265.316 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H315, H319, H335
Precautionary statements	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

LSN2463359 is a drug used in scientific research.

Mechanism of action

LSN2463359 is a positive allosteric modulator of the mGluR₅, which means it increases the activity of glutamate (an excitatory neurotransmitter) at this receptor.

Potential uses

A study has found that LSN2463359 and similar drugs can be used as a treatment to some aspects of cognitive deficits in schizophrenia. Another study also mention that it could be used in the treatment of schizophrenia due to the potential interactions between NMDA receptors and mGluR₅.

References

↑ "N-Isopropyl-5-(pyridin-4-ylethynyl)picolinamide". pubchem.ncbi.nlm.nih.gov.
↑ Gilmour, Gary; Broad, Lisa M.; Wafford, Keith A.; Britton, Thomas; Colvin, Ellen M.; Fivush, Adam; Gastambide, Francois; Getman, Brian; Heinz, Beverly A.; McCarthy, Andrew P.; Prieto, Lourdes; Shanks, Elaine; Smith, Janice W.; Taboada, Lorena; Edgar, Dale M. (January 2013). "In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat". Neuropharmacology. 64: 224–239. doi:10.1016/j.neuropharm.2012.07.030. ISSN 1873-7064. PMID 22884720.
↑ Gastambide, Francois; Cotel, Marie-Caroline; Gilmour, Gary; O'Neill, Michael J.; Robbins, Trevor W.; Tricklebank, Mark D. (March 2012). "Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator". Neuropsychopharmacology. 37 (4): 1057–1066. doi:10.1038/npp.2011.298. ISSN 1740-634X. PMC 3280638. PMID 22129780.
↑ Gastambide, Francois; Gilmour, Gary; Robbins, Trevor W.; Tricklebank, Mark D. (January 2013). "The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat". Neuropharmacology. 64: 240–247. doi:10.1016/j.neuropharm.2012.07.039. ISSN 1873-7064. PMID 22884612.

[1] "N-Isopropyl-5-(pyridin-4-ylethynyl)picolinamide". pubchem.ncbi.nlm.nih.gov.

[2] Gilmour, Gary; Broad, Lisa M.; Wafford, Keith A.; Britton, Thomas; Colvin, Ellen M.; Fivush, Adam; Gastambide, Francois; Getman, Brian; Heinz, Beverly A.; McCarthy, Andrew P.; Prieto, Lourdes; Shanks, Elaine; Smith, Janice W.; Taboada, Lorena; Edgar, Dale M. (January 2013). "In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat". Neuropharmacology. 64: 224–239. doi:10.1016/j.neuropharm.2012.07.030. ISSN 1873-7064. PMID 22884720.

[3] Gastambide, Francois; Cotel, Marie-Caroline; Gilmour, Gary; O'Neill, Michael J.; Robbins, Trevor W.; Tricklebank, Mark D. (March 2012). "Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator". Neuropsychopharmacology. 37 (4): 1057–1066. doi:10.1038/npp.2011.298. ISSN 1740-634X. PMC 3280638. PMID 22129780.

[4] Gastambide, Francois; Gilmour, Gary; Robbins, Trevor W.; Tricklebank, Mark D. (January 2013). "The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat". Neuropharmacology. 64: 240–247. doi:10.1016/j.neuropharm.2012.07.039. ISSN 1873-7064. PMID 22884612.