Little Bill

Glover household

• William "Little Bill" Glover Jr. (voiced by Xavier Pritchett) is an inquisitive 5-year-old boy. He has a knack for storytelling and often finds himself daydreaming his own fantasy worlds. Little Bill's personality was inspired by Bill Cosby's late son, Ennis Cosby, and his catchphrase "Hello, friend!" was a greeting that Ennis often used.
• William "Big Bill" Glover Sr. (voiced by Gregory Hines) is the city's building inspector who is Little Bill, Bobby, and April's father, and Brenda's husband. He is nicknamed Big Bill since both he and his son are named Bill. In an interview, Bill Cosby said, "I am Big Bill."
• Brenda Glover (née Kendall; voiced by Phylicia Rashad) is Little Bill, Bobby, and April's mother, and Big Bill's wife. Brenda's voice actress, Phylicia Rashad, had previously played Clair Huxtable (wife to Cosby's character, Cliff Huxtable) on the 1980s sitcom The Cosby Show and Ruth Lucas (wife to Cosby's other character, Hilton Lucas) on Cosby.
• April Glover (voiced by Monique Beasley) is the 10-year-old oldest child and only daughter of Brenda and Big Bill. She tends to be competitive and plays basketball.
• Robert "Bobby" Glover (voiced by Devon Malik Beckford in Season 1 and Tyler James Williams in Season 2) is the middle child and the oldest son of the Glover children. He is an 8-year-old Boy Scout and plays the violin.
• Alice "Alice the Great" Kendall (voiced by Ruby Dee and Anika Walker in a flashback in "Good Ol' Lightning") is the maternal great-grandmother of Little Bill, Bobby, April, and Jamal. Alice is also Brenda and Deborah's grandmother. She is in her seventies and lives with the family.
• Elephant is the family's pet, a small, light golden hamster who lives in Little Bill's bedroom. He often rolls all over the house in a plastic hamster ball. He was named after Little Bill's favorite animal.

Family members, friends and neighbors

• Captain Brainstorm (voiced by Bill Cosby) is Little Bill's favorite superhero. He is an astronaut with his own TV show, Space Explorers. He rides an orange rocket and wears an orange spacesuit.
• Miss Aisha Murray (voiced by Ayo Haynes in Season 1 and Melanie Nicholls-King in Season 2) is Little Bill's brightest kindergarten teacher. She has brown dreads and wears purple glasses. She marries Dr. Winthorp Clinkscales in "Miss Murray's Wedding".
• Fuchsia Glover (voiced by Nakia Williams in the first episode and Kianna Underwood for the rest) is the paternal cousin of Little Bill, Bobby, and April. Her mother is named Vanessa and her father is named Al. She is known for always speaking her mind.
• Andrew Mulligan (voiced by Zach Tyler Eisen) is an Irish-American boy who is Little Bill's best friend. He lives two houses away from Little Bill. He has an active imagination like Little Bill, and they often join each other in fantasy sequences. He has a pet dog named Farfy.
• Kiku Natsuko (voiced by Eunice Cho) is an Asian-American friend of Little Bill's. She likes to be creative, putting on puppet shows, and making artwork. She is very ambitious and wants to be president when she grows up.
• Uncle Alan "Al" Glover (voiced by Michael Green) is Big Bill's brother, Brenda's brother in-law, Fuchsia's father, Vanessa's husband, and Little Bill, Bobby, and April's paternal uncle. He works at the convenience store while living in a town.
• Monty (voiced by Cole Hawkins) is the disabled grandson of Alice the Great's friend Emmaline. He uses a wheelchair to get around, because of being born with cerebral palsy. Later in the series, he joins Little Bill's class.
• Dorado (voiced by Vincent Canales) is Little Bill's friend who is of Puerto Rican ancestry.
• Valencia (voiced by Rosie Perez in Season 1, and Mary Birdsong in Season 4) is Dorado's single mother who is also of Puerto Rican ancestry. She speaks English and Spanish with a Puerto Rican accent.
• Michael Riley (voiced by Muhammad Cunningham) is a classmate of Little Bill's who moves to the neighborhood from the Southern city of Miami. At first, he is somewhat of a bully by playing ranking with Little Bill, but he reforms and befriends him in the end.
• Mrs. Shapiro (voiced by Madeline Kahn in her first appearance, and later by Kathy Najimy after Kahn's death) is Little Bill's 50-year-old red haired neighbor who wears glasses. In "Same Moon, Same Sun, Same Star", Mrs. Shapiro and her brunette sister, Mimi, grew up in Hawaii. In the same episode, Mrs. Shapiro moves back to Hawaii to live with Mimi because she misses her.
• Dr. Winthrop Clinkscales (voiced by Christopher Grossett) is Mrs. Murray's husband, whom she married in "Miss Murray's Wedding".
• Mr. Miguel Rojas (voiced by Victor Argo) is an elderly Mexican-American man who speaks two languages: English and Spanish with a Mexican accent. In "The New Neighbors", he and his dog, Miguelito "Lito", move into Mrs. Shapiro's old house after Mrs. Shapiro moved away.
• Mr. Clark Terry (voiced by Clark Terry) is Alice the Great and Little Bill's new friend.
• Baby Jamal Welsh is Little Bill, Bobby and April's maternal baby cousin (on his mother's side), son of Aunt Deborah (Brenda's sister) and Uncle Gary.
• Percy Mulch (voiced by Doug E. Doug) is the African-Caribbean owner of a pet shop.
• Mr. Williams (voiced by Mike Mearian) is a music store owner.
• Aunt Deborah Kendall (voiced by Grace Garland) is Brenda's younger sister, Big Bill's sister in-law, Little Bill, Bobby and April's maternal aunt, Uncle Gary's wife (voiced by Weston Clark) and Baby Jamal's mother.

Main home video releases

Episodes on Nick Jr. compilation DVDs