MARVELD2

MARVELD2
Identifiers
Aliases	MARVELD2, DFNB49, MARVD2, MRVLDC2, Tric, MARVEL domain containing 2
External IDs	OMIM: 610572; MGI: 2446166; GeneCards: MARVELD2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	69,444,330 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	100,753,479 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gonad; ; duodenum; ; liver; ; rectum; ; mucosa of transverse colon; ; testicle; ; thyroid gland; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	otic vesicle; ; saccule; ; otic placode; ; Hindgut; ; urothelium; ; conjunctival fornix; ; medullary collecting duct; ; Paneth cell; ; epithelium of small intestine; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; basolateral plasma membrane; apical plasma membrane; cytoplasmic vesicle; membrane; tricellular tight junction; bicellular tight junction; cell junction; paranodal junction; Schmidt-Lanterman incisure;
Biological process	establishment of endothelial barrier; cell-cell junction organization; hearing; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	153562
	218518
	ENSG00000274671; ENSG00000152939
	ENSMUSG00000021636
	Q8N4S9
	Q3UZP0
	NM_001038603; NM_001244734; NM_144724
	NM_001038602; NM_178410
	NP_001033692; NP_001231663
	NP_001033691; NP_848497
	Wikidata
View/Edit Human	View/Edit Mouse

MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene.

References

1 2 3 ENSG00000152939 GRCh38: Ensembl release 89: ENSG00000274671, ENSG00000152939 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021636 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Riazuddin S, Ahmed ZM, Fanning AS, Lagziel A, Kitajiri S, Ramzan K, Khan SN, Chattaraj P, Friedman PL, Anderson JM, Belyantseva IA, Forge A, Riazuddin S, Friedman TB (Dec 2006). "Tricellulin is a tight-junction protein necessary for hearing". Am J Hum Genet. 79 (6): 1040–51. doi:10.1086/510022. PMC 1698716. PMID 17186462.
↑ "Entrez Gene: MARVELD2 MARVEL domain containing 2".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ikenouchi J, Furuse M, Furuse K, et al. (2006). "Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells". J. Cell Biol. 171 (6): 939–45. doi:10.1083/jcb.200510043. PMC 2171318. PMID 16365161.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Ramzan K, Shaikh RS, Ahmad J, et al. (2005). "A new locus for nonsyndromic deafness DFNB49 maps to chromosome 5q12.3-q14.1". Hum. Genet. 116 (1–2): 17–22. doi:10.1007/s00439-004-1205-8. PMID 15538632. S2CID 39267757.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000152939 GRCh38: Ensembl release 89: ENSG00000274671, ENSG00000152939 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021636 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17186462-5] Riazuddin S, Ahmed ZM, Fanning AS, Lagziel A, Kitajiri S, Ramzan K, Khan SN, Chattaraj P, Friedman PL, Anderson JM, Belyantseva IA, Forge A, Riazuddin S, Friedman TB (Dec 2006). "Tricellulin is a tight-junction protein necessary for hearing". Am J Hum Genet. 79 (6): 1040–51. doi:10.1086/510022. PMC 1698716. PMID 17186462.

[entrez-6] "Entrez Gene: MARVELD2 MARVEL domain containing 2".

v t e Proteins of epithelium
Lateral/cell–cell	Cell adhesion molecules: Adherens junction Cadherin Desmosome Desmoglein Ion channels: Gap junction/Connexon Connexin Cytoskeleton: Desmosome Desmoplakin Plakoglobin Tonofibril other membrane proteins: Tight junction Claudin Occludin MARVELD2
Basal/cell–matrix	Basal lamina Hemidesmosome/Tonofibril Focal adhesion Costamere
Apical	Cilia/Kinocilium Microvilli/Stereocilia (STRC)

MARVELD2

References

Further reading