PALS2

PALS2
Identifiers
Aliases	PALS2, VAM1, membrane palmitoylated protein 6, protein associated with LIN7 2, MAGUK family member, protein associated with LIN7 2, MAGUK p55 family member, MPP6, VAM-1, p55T
External IDs	OMIM: 606959; MGI: 1927340; GeneCards: PALS2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	24,694,193 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	50,175,919 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; islet of Langerhans; ; testicle; ; tibia; ; left testis; ; gallbladder; ; right testis; ; gonad; ; sural nerve; ; sperm;
	Top expressed in
	interventricular septum; ; medullary collecting duct; ; right kidney; ; seminiferous tubule; ; endothelial cell of lymphatic vessel; ; temporal muscle; ; tail of embryo; ; proximal tubule; ; spermatid; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein binding;
Cellular component	plasma membrane; extracellular exosome; membrane;
Biological process	protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51678
	56524
	ENSG00000105926
	ENSMUSG00000038388
	Q9NZW5
	Q9JLB0
	NM_001303037; NM_016447
NM_001164733; NM_001164734; NM_008016; NM_019939; NM_001361247;
	NM_001361248
	NP_001289966; NP_057531
	NP_001158205; NP_001158206; NP_064323; NP_001348176; NP_001348177
	Wikidata
View/Edit Human	View/Edit Mouse

Protein PALS2 is a protein that in humans is encoded by the PALS2 gene (previously MPP6).

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1), ZO1-like (see TJP1), p55-like (see MPP1), and LIN2-like (see CASK), based on their size and the presence of additional domains. PALS2/MPP6 is a member of the p55-like MAGUK subfamily.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105926 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038388 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
↑ Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
1 2 "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105926 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038388 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10753959-5] Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (May 2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J Biol Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.

[pmid11311936-6] Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (Apr 2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim Biophys Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.

[entrez-7] 1 2 "Entrez Gene: MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)".

PALS2

See also

References

Further reading