Macrophage mannose receptor 1

MRC1
Identifiers
Aliases	MRC1, CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR, mannose receptor, C type 1, mannose receptor C-type 1
External IDs	OMIM: 153618; MGI: 97142; GeneCards: MRC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EGG, 1EGI
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.33 Start 17,809,348 bp End 17,911,164 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A2|2 10.46 cM Start 14,234,203 bp End 14,336,868 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung visceral pleura secondary oocyte decidua pericardium superficial temporal artery synovial membrane synovial joint skin of hip right ventricle Top expressed in stroma of bone marrow vestibular sensory epithelium dermis umbilical cord carotid body tunica adventitia of aorta skin of external ear calvaria efferent ductule sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mannose binding transmembrane signaling receptor activity carbohydrate binding virus receptor activity Cellular component integral component of membrane cell surface endosome plasma membrane integral component of plasma membrane endosome membrane membrane Biological process cellular response to interferon-gamma cellular response to interleukin-4 viral entry into host cell viral process cellular response to lipopolysaccharide endocytosis receptor-mediated endocytosis signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4360 17533 Ensembl ENSG00000260314 ENSMUSG00000026712 UniProt P22897 Q61830 RefSeq (mRNA) NM_002438 NM_001009567 NM_008625 RefSeq (protein) NP_002429 NP_032651 Location (UCSC) Chr 10: 17.81 – 17.91 Mb Chr 2: 14.23 – 14.34 Mb PubMed search
Wikidata
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Macrophage mannose receptor 1, also known as mannose receptor C-type 1, is a protein that in humans is encoded by the MRC1 gene.

Function

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.