Perry holds both Canadian and American citizenship.
Perry dated Yasmine Bleeth in 1995. He also dated Julia Roberts from 1995 to 1996. Perry had to write and submit a paper on quantum physics to Roberts in order for her to appear on Friends. He later dated Lizzy Caplan from 2006 to 2012.
Perry completed a 28-day program in 1997 for a Vicodin addiction. His weight fluctuated drastically over the next few years and once dropped down to 145 pounds (66 kg). He lost 20 pounds (9.1 kg) in 2000 due to pancreatitis. He again entered rehab in February 2001 for addiction to Vicodin, methadone, amphetamines, and alcohol. He was filming Serving Sara in Texas when he suffered severe stomach pains, and flew to Los Angeles to check into Marina del Rey's Daniel Freeman Hospital. Perry's publicist, Lisa Kasteler, confirmed his rehab stay. Perry later revealed that due to his addiction issues he does not remember three years of his time on Friends, "somewhere between season three and six."
Perry is a fan of the Fallout video game series. On a 2009 episode of The Ellen DeGeneres Show, he gifted DeGeneres a copy of Fallout 3. This prompted game studio Bethesda to cast him in the next installment of the series, Fallout: New Vegas.
In 2011, as a celebrity spokesperson for the National Association of Drug Court Professionals, Perry went to Capitol Hill to lobby members of Congress in support of funding for drug courts.
Perry received a Champion of Recovery award in May 2013 from the White House Office of National Drug Control Policy for opening Perry House, a sober living home situated in his former mansion in Malibu, California.
In August 2018, it was reported that Perry had abdominal surgery to repair a gastrointestinal perforation. On September 15, 2018, he revealed in a tweet that he had spent 3 months recovering in the hospital, suggesting the surgery took place in June 2018.
He got engaged to Molly Hurwitz, a literary manager, in November 2020. They were first rumoured to be dating in December 2019, when they had reportedly spent Christmas together.