Methoxyetomidate

Methoxyetomidate
Clinical data
Other namesET-26; Moxetomidate
Identifiers
  • 2-methoxyethyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H18N2O3
Molar mass274.320 g·mol−1
3D model (JSmol)
  • [C@H](C)(N1C(C(OCCOC)=O)=CN=C1)C2=CC=CC=C2
  • InChI=InChI=1S/C15H18N2O3/c1-12(13-6-4-3-5-7-13)17-11-16-10-14(17)15(18)20-9-8-19-2/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1
  • Key:JJSJTELMIQBHDE-GFCCVEGCSA-N

Methoxyetomidate (Methoxyethyl etomidate) is an investigational anesthetic agent being developed by Jinzhou Ahon Pharmaceutical Co., Ltd. It is a short-acting intravenous anesthetic that acts as a positive allosteric modulator of GABAA receptors. As of 2024, methoxyetomidate is undergoing Phase 3 clinical trials for use in anesthesia.

References

  1. 1 2 "ET-26 Methoxyetomidate Hydrochloride Development Information". Synapse by Patsnap. Retrieved 2024-11-23.
  2. ↑ Wang B, Chen S, Yang J, Yang L, Liu J, Zhang W (2017). "ET-26 hydrochloride (ET-26 HCl) has similar hemodynamic stability to that of etomidate in normal and uncontrolled hemorrhagic shock (UHS) rats". PLOS ONE. 12 (8) e0183439. Bibcode:2017PLoSO..1283439W. doi:10.1371/journal.pone.0183439. PMC 5557577. PMID 28813523.
  3. ↑ Liu X, Song H, Yang J, Zhou C, Kang Y, Yang L, Liu J, Zhang W. The etomidate analog ET-26 HCl retains superior myocardial performance: Comparisons with etomidate in vivo and in vitro. PLoS One. 2018 Jan 11;13(1):e0190994. doi: 10.1371/journal.pone.0190994. PMID: 29324898Liu X, Song H, Yang J, Zhou C, Kang Y, Yang L, Liu J, Zhang W. The etomidate analog ET-26 HCl retains superior myocardial performance: Comparisons with etomidate in vivo and in vitro. PLoS One. 2018 Jan 11;13(1):e0190994. doi:10.1371/journal.pone.0190994 PMID 29324898
  4. ↑ "ET-26 Clinical Trials Overview". Synapse by Patsnap. Retrieved 2024-11-23.
  5. ↑ Valk BI, Struys MMRF. Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2021 Oct;60(10):1253-1269. doi:10.1007/s40262-021-01038-6 PMID 34060021
  6. ↑ Philip AB, Brohan J, Goudra B. The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review. CNS Drugs. 2025 Jan;39(1):39-54. doi:10.1007/s40263-024-01128-6 PMID 39465449
  7. ↑ Chen Y, Wu L, Lang B, Zhang W, Chen S. Recent progress in the development of etomidate analogues. Front Pharmacol. 2025 Oct 14;16:1614865. doi:10.3389/fphar.2025.1614865 PMID 41164750
  8. ↑ Chittoria K, Sharma A. The novel etomidate analog: A potential induction agent. Saudi J Anaesth. 2025 Oct-Dec;19(4):614-616. doi:10.4103/sja.sja_503_25 PMID 40994477