Metixene

Metixene
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N04AA03 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Identifiers
	IUPAC name 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;
CAS Number	4969-02-2 ;
PubChem CID	4167;
IUPHAR/BPS	7232;
DrugBank	DB00340;
ChemSpider	4023;
UNII	32VY6L26ZW;
KEGG	D08209;
ChEBI	CHEBI:51024;
ChEMBL	ChEMBL1201342;
CompTox Dashboard (EPA)	DTXSID1047867 ;
ECHA InfoCard	100.023.282
Chemical and physical data
Formula	C20H23NS
Molar mass	309.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24;
	InChI InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3; Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N;
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Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent. It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.

References

↑ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
↑ Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.
↑ Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. 133 (24) e161142. doi:10.1172/JCI161142. PMC 10721147. PMID 37847564.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.

[3] Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. 133 (24) e161142. doi:10.1172/JCI161142. PMC 10721147. PMID 37847564.

Metixene

See also

References