Michael Stuart Brown

Michael Brown
ForMemRS
Michael Brown ForMemRS
Born	Michael Stuart Brown; April 13, 1941 (age 85); Brooklyn, New York, U.S.
Education	University of Pennsylvania; University of Pennsylvania School of Medicine;
Known for	Regulation of cholesterol metabolism
Spouse	Alice Lapin (m. 1964)[citation needed]
Children	two[citation needed]
Awards	Heinrich Wieland Prize (1974); Richard Lounsbery Award (1979); Louisa Gross Horwitz Prize (1984); William Allan Award (1985); Nobel Prize in Physiology or Medicine (1985); National Medal of Science (1988);
	Scientific career
Fields	Biology
Website	profiles.utsouthwestern.edu/profile/10894/michael-brown.html

Michael Stuart Brown ForMemRS NAS AAA&S APS (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism.

Early life and education

Brown was born in Brooklyn, New York, on April 13, 1941, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman. His family is Jewish. He graduated from Cheltenham High School in Wyncote, Pennsylvania. Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966.^{[citation needed]}

Career

Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - receptor-mediated endocytosis. Their findings led to the development of statin drugs, the cholesterol-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States.^{[citation needed]} Their discoveries are improving more lives every year, both in the US and around the world.^{[citation needed]} New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein prenylation) in cancer. In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L. Goldstein (co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received the National Medal of Science for his contributions to medicine.

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the sterol regulatory element binding proteins (SREBPs). Since 1993, Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.

Brown holds the W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine.^{[citation needed]}

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Awards and honors

Brown has won numerous awards and honors, including:

2016 - Keynote Speaker at the Congress of Future Medical Leaders
2011 - Stadtman Distinguished Scientist Award, American Society for Biochemistry and Molecular Biology
2007 - Builders of Science Award, Research!America
2005 - Woodrow Wilson Award for Public Service
2005 - Herbert Tabor Award, American Society for Biochemistry and Molecular Biology
2003 - Albany Medical Center Prize
2002 - Kober Medal, Association of American Physicians
1999 - Warren Alpert Foundation Prize, Harvard Medical School
1991 - Elected a Foreign Member of the Royal Society (ForMemRS)
1987 - Elected member of the American Philosophical Society
1986 - Golden Plate Award of the American Academy of Achievement
1985 - Nobel Prize for physiology and medicine
1985 - Albert Lasker Award for Basic Medical Research
1985 - William Allan Award, American Society of Human Genetics
1984 - Louisa Gross Horwitz Prize (Columbia University)
1981 - Gairdner Foundation International Award
1981 - Elected member of the American Academy of Arts and Sciences
1980 - elected member of the National Academy of Sciences
1979 - Lounsbery Award, U.S. National Academy of Sciences
1978 - Passano Award, Johns Hopkins University
1976 - Pfizer Award in Enzyme Chemistry, American Chemical Society
1974 - Heinrich Wieland Prize

Bibliography

Brown MS, Goldstein JL (July 1974). "Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man". Science. 185 (4145): 61–3. Bibcode:1974Sci...185...61B. doi:10.1126/science.185.4145.61. PMID 4366052. S2CID 31493564.
Brown MS, Goldstein JL (November 1975). "Regulation of the activity of the low density lipoprotein receptor in human fibroblasts". Cell. 6 (3): 307–16. doi:10.1016/0092-8674(75)90182-8. PMID 212203. S2CID 28312936.
Goldstein JL, Basu SK, Brunschede GY, Brown MS (January 1976). "Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans". Cell. 7 (1): 85–95. doi:10.1016/0092-8674(76)90258-0. PMID 181140. S2CID 23110979.
Brown MS, Goldstein JL (January 1976). "Receptor-mediated control of cholesterol metabolism". Science. 191 (4223): 150–4. Bibcode:1976Sci...191..150B. doi:10.1126/science.174194. PMID 174194.
Goldstein JL, Sobhani MK, Faust JR, Brown MS (October 1976). "Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus". Cell. 9 (2): 195–203. doi:10.1016/0092-8674(76)90110-0. PMID 184960. S2CID 26944871.
Brown MS, Goldstein JL (December 1976). "Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein". Cell. 9 (4 PT 2): 663–74. doi:10.1016/0092-8674(76)90130-6. PMID 189940. S2CID 6706608.
Anderson RG, Brown MS, Goldstein JL (March 1977). "Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts". Cell. 10 (3): 351–64. doi:10.1016/0092-8674(77)90022-8. PMID 191195. S2CID 25657719.
Goldstein JL, Brown MS, Stone NJ (November 1977). "Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic". Cell. 12 (3): 629–41. doi:10.1016/0092-8674(77)90263-X. PMID 200368. S2CID 13211975.
Anderson RG, Goldstein JL, Brown MS (1977). "A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts". Nature. 270 (5639): 695–9. Bibcode:1977Natur.270..695A. doi:10.1038/270695a0. PMID 201867. S2CID 4152556.
Anderson RG, Vasile E, Mello RJ, Brown MS, Goldstein JL (November 1978). "Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution". Cell. 15 (3): 919–33. doi:10.1016/0092-8674(78)90276-3. PMID 215316. S2CID 35345591.
Goldstein JL, Anderson RG, Brown MS (June 1979). "Coated pits, coated vesicles, and receptor-mediated endocytosis". Nature. 279 (5715): 679–85. Bibcode:1979Natur.279..679G. doi:10.1038/279679a0. PMID 221835. S2CID 4353842.
Mello RJ, Brown MS, Goldstein JL, Anderson RG (July 1980). "LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment". Cell. 20 (3): 829–37. doi:10.1016/0092-8674(80)90329-3. PMID 6251975. S2CID 23996668.
Brown MS, Kovanen PT, Goldstein JL (May 1981). "Regulation of plasma cholesterol by lipoprotein receptors". Science. 212 (4495): 628–35. Bibcode:1981Sci...212..628B. doi:10.1126/science.6261329. PMID 6261329.
Basu SK, Goldstein JL, Anderson RG, Brown MS (May 1981). "Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts". Cell. 24 (2): 493–502. doi:10.1016/0092-8674(81)90340-8. PMID 6263497. S2CID 29553611.
Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS (October 1982). "Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia". Cell. 30 (3): 715–24. doi:10.1016/0092-8674(82)90276-8. PMID 6291781. S2CID 30013697.
Basu SK, Goldstein JL, Brown MS (February 1983). "Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages". Science. 219 (4586): 871–3. Bibcode:1983Sci...219..871B. doi:10.1126/science.6823554. PMID 6823554.
Brown MS, Anderson RG, Goldstein JL (March 1983). "Recycling receptors: the round-trip itinerary of migrant membrane proteins". Cell. 32 (3): 663–7. doi:10.1016/0092-8674(83)90052-1. PMID 6299572. S2CID 34919831.
Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL (March 1983). "The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor". Cell. 32 (3): 941–51. doi:10.1016/0092-8674(83)90079-X. PMID 6299582. S2CID 39955408.
Larkin JM, Brown MS, Goldstein JL, Anderson RG (May 1983). "Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts". Cell. 33 (1): 273–85. doi:10.1016/0092-8674(83)90356-2. PMID 6147196. S2CID 22848187.
Orci L, Brown MS, Goldstein JL, Garcia-Segura LM, Anderson RG (April 1984). "Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells". Cell. 36 (4): 835–45. doi:10.1016/0092-8674(84)90033-3. PMID 6705048. S2CID 24586649.
Chin DJ, Gil G, Russell DW, et al. (1984). "Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum". Nature. 308 (5960): 613–7. Bibcode:1984Natur.308..613C. doi:10.1038/308613a0. PMID 6546784. S2CID 4308995.
Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL (June 1984). "Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor". Cell. 37 (2): 577–85. doi:10.1016/0092-8674(84)90388-X. PMID 6327078. S2CID 29839468.
Reynolds GA, Basu SK, Osborne TF, et al. (August 1984). "HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions". Cell. 38 (1): 275–85. doi:10.1016/0092-8674(84)90549-X. PMID 6088070. S2CID 11644830.
Yamamoto T, Davis CG, Brown MS, et al. (November 1984). "The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA". Cell. 39 (1): 27–38. doi:10.1016/0092-8674(84)90188-0. PMID 6091915. S2CID 25822170.
Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW (January 1985). "Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains". Science. 227 (4683): 140–6. Bibcode:1985Sci...227..140L. doi:10.1126/science.3155573. PMC 4449727. PMID 3155573.
Südhof TC, Goldstein JL, Brown MS, Russell DW (May 1985). "The LDL receptor gene: a mosaic of exons shared with different proteins". Science. 228 (4701): 815–22. Bibcode:1985Sci...228..815S. doi:10.1126/science.2988123. PMC 4450672. PMID 2988123.
Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI (May 1985). "Cassette of eight exons shared by genes for LDL receptor and EGF precursor". Science. 228 (4701): 893–5. Bibcode:1985Sci...228..893S. doi:10.1126/science.3873704. PMID 3873704.
Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS (May 1985). "Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme". Cell. 41 (1): 249–58. doi:10.1016/0092-8674(85)90078-9. PMID 3995584. S2CID 22530611.
Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ (July 1985). "Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain". Cell. 41 (3): 735–43. doi:10.1016/S0092-8674(85)80054-4. PMID 3924410. S2CID 27773467.
Osborne TF, Goldstein JL, Brown MS (August 1985). "5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription". Cell. 42 (1): 203–12. doi:10.1016/S0092-8674(85)80116-1. PMID 3860301. S2CID 37319421.
Brown MS, Goldstein JL (1985). "Scavenger cell receptor shared". Nature. 316 (6030): 680–1. doi:10.1038/316680a0. PMID 4033768. S2CID 4349775.
Brown MS, Goldstein JL (April 1986). "A receptor-mediated pathway for cholesterol homeostasis". Science. 232 (4746): 34–47. Bibcode:1986Sci...232...34B. doi:10.1126/science.3513311. PMID 3513311.
Davis CG, Lehrman MA, Russell DW, Anderson RG, Brown MS, Goldstein JL (April 1986). "The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors". Cell. 45 (1): 15–24. doi:10.1016/0092-8674(86)90533-7. PMID 3955657. S2CID 8147673.
Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW (June 1986). "Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit". Science. 232 (4755): 1230–7. Bibcode:1986Sci...232.1230Y. doi:10.1126/science.3010466. PMC 4451858. PMID 3010466.
Lehrman MA, Goldstein JL, Russell DW, Brown MS (March 1987). "Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia". Cell. 48 (5): 827–35. doi:10.1016/0092-8674(87)90079-1. PMID 3815525. S2CID 35887205.
Südhof TC, Russell DW, Brown MS, Goldstein JL (March 1987). "42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter". Cell. 48 (6): 1061–9. doi:10.1016/0092-8674(87)90713-6. PMID 3030558. S2CID 42788737.
Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS (1987). "Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region". Nature. 326 (6115): 760–5. Bibcode:1987Natur.326..760D. doi:10.1038/326760a0. PMID 3494949. S2CID 4347695.
Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE (March 1988). "Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice". Science. 239 (4845): 1277–81. Bibcode:1988Sci...239.1277H. doi:10.1126/science.3344433. PMID 3344433.
Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS (July 1990). "Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides". Cell. 62 (1): 81–8. doi:10.1016/0092-8674(90)90242-7. PMID 2194674. S2CID 30887422.
Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL (November 1990). "Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors". Science. 250 (4985): 1273–5. Bibcode:1990Sci...250.1273Y. doi:10.1126/science.2244210. PMID 2244210.
Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL (May 1991). "Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit". Cell. 65 (3): 429–34. doi:10.1016/0092-8674(91)90460-G. PMID 2018975. S2CID 54388220.
Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS (July 1991). "cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1". Cell. 66 (2): 327–34. doi:10.1016/0092-8674(91)90622-6. PMID 1855253. S2CID 36722957.
Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL (September 1992). "Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product". Cell. 70 (6): 1049–57. doi:10.1016/0092-8674(92)90253-9. PMID 1525821. S2CID 26223659.
Brown MS, Goldstein JL (October 1992). "Koch's postulates for cholesterol". Cell. 71 (2): 187–8. doi:10.1016/0092-8674(92)90346-E. PMID 1423585. S2CID 33048207.
Andres DA, Seabra MC, Brown MS, et al. (June 1993). "cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein". Cell. 73 (6): 1091–9. doi:10.1016/0092-8674(93)90639-8. PMID 8513495. S2CID 26120573.
Yokoyama C, Wang X, Briggs MR, et al. (October 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell. 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. S2CID 2784016.
Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (March 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.
Wang X, Sato R, Brown MS, Hua X, Goldstein JL (April 1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis". Cell. 77 (1): 53–62. doi:10.1016/0092-8674(94)90234-8. PMID 8156598. S2CID 44899129.
Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL (June 1996). "Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment". Cell. 85 (7): 1037–46. doi:10.1016/S0092-8674(00)81304-5. PMID 8674110. S2CID 6130686.
Hua X, Nohturfft A, Goldstein JL, Brown MS (November 1996). "Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein". Cell. 87 (3): 415–26. doi:10.1016/S0092-8674(00)81362-8. PMID 8898195. S2CID 1963192.
Brown MS, Goldstein JL (May 1997). "The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor". Cell. 89 (3): 331–40. doi:10.1016/S0092-8674(00)80213-5. PMID 9150132. S2CID 17882616.
DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ (December 1999). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell. 99 (7): 703–12. doi:10.1016/S0092-8674(00)81668-2. PMID 10619424.
Brown MS, Ye J, Rawson RB, Goldstein JL (February 2000). "Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans". Cell. 100 (4): 391–8. doi:10.1016/S0092-8674(00)80675-3. PMID 10693756. S2CID 12194770.
Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ (August 2000). "Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes". Cell. 102 (3): 315–23. doi:10.1016/S0092-8674(00)00037-4. PMID 10975522. S2CID 18054832.
Yang T, Espenshade PJ, Wright ME, et al. (August 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. S2CID 15052132.

References

↑ "Biography: Michael S. Brown". The Notable Names Database. Soylent Communications. 2008. Retrieved June 15, 2008.
↑ "Michael Brown - Nobel Prize Inspiration Initiative". Nobelprizeii.org. Retrieved November 6, 2015.
1 2 "Michael S. Brown - Biographical". Nobelprize.org. April 13, 1941. Retrieved November 6, 2015.
↑ "Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis". Nobelprize.org. December 8, 1985. Retrieved November 6, 2015.
↑ "BROWN (Brown), Michael, photo, biography". Persona.rin.ru. April 13, 1941. Retrieved November 6, 2015.
↑ "Jewish Nobel Prize Winners in Medicine". www.jinfo.org. Retrieved March 30, 2023.
↑ "Earl and Thressa Stadtman Distinguished Scientist Award". Asbmb.org. Retrieved November 6, 2015.
↑ "University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award". Research!America. March 21, 2007. Retrieved November 6, 2015.
↑ Archived October 8, 2013, at the Wayback Machine
↑ "Herbert Tabor Research Award". Asbmb.org. Retrieved November 6, 2015.
↑ "Albany Medical College: 2003". Amc.edu. August 14, 2015. Retrieved November 6, 2015.
↑ Daniel W. Foster; Jean D. Wilson. "Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown" (PDF). Jci.org. Retrieved November 6, 2015.
↑ Archived April 10, 2012, at the Wayback Machine
↑ "Professor Michael Brown ForMemRS". London: Royal Society. Archived from the original on November 6, 2015.
↑ "APS Member History".
↑ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
↑ "The Nobel Prize in Physiology or Medicine 1985". nobelprize.org. The Nobel Foundation. Retrieved October 18, 2022.
↑ "1985 Basic Medical Research Award". The Lasker Foundation. September 16, 2007. Archived from the original on September 13, 2015. Retrieved November 6, 2015.
↑ "Past ASHG Award Recipients". ASHG. Archived from the original on October 3, 2014. Retrieved November 6, 2015.
↑ "Horwitz Prize Awardees". cuimc.columbia.edu. Columbia University. June 20, 2018. Retrieved October 18, 2022.
↑ "Joseph L. Goldstein". Gairdner. Retrieved November 6, 2015.
↑ "Michael Stuart Brown". October 3, 2024.
↑ "Michael Brown". www.nasonline.org. Retrieved March 23, 2018.
↑ "Richard Lounsbery Award". Nasonline.org. Archived from the original on November 26, 2011. Retrieved November 6, 2015.
↑ Archived October 7, 2012, at the Wayback Machine
↑ "Pfizer Award in Enzyme Chemistry". Divbiolchem.org. Retrieved November 6, 2015.
↑ "Heinrich Wieland Prize Laureates 1970 - 1979". Boehringer Ingelheim Stiftung. Retrieved October 18, 2022.

External links

Michael S. Brown on Nobelprize.org

[1] "Biography: Michael S. Brown". The Notable Names Database. Soylent Communications. 2008. Retrieved June 15, 2008.

[2] "Michael Brown - Nobel Prize Inspiration Initiative". Nobelprizeii.org. Retrieved November 6, 2015.

[nobelprize1985-3] 1 2 "Michael S. Brown - Biographical". Nobelprize.org. April 13, 1941. Retrieved November 6, 2015.

[4] "Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis". Nobelprize.org. December 8, 1985. Retrieved November 6, 2015.

[5] "BROWN (Brown), Michael, photo, biography". Persona.rin.ru. April 13, 1941. Retrieved November 6, 2015.

[6] "Jewish Nobel Prize Winners in Medicine". www.jinfo.org. Retrieved March 30, 2023.

[7] "Earl and Thressa Stadtman Distinguished Scientist Award". Asbmb.org. Retrieved November 6, 2015.

[8] "University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award". Research!America. March 21, 2007. Retrieved November 6, 2015.

[9] Archived October 8, 2013, at the Wayback Machine

[10] "Herbert Tabor Research Award". Asbmb.org. Retrieved November 6, 2015.

[11] "Albany Medical College: 2003". Amc.edu. August 14, 2015. Retrieved November 6, 2015.

[12] Daniel W. Foster; Jean D. Wilson. "Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown" (PDF). Jci.org. Retrieved November 6, 2015.

[13] Archived April 10, 2012, at the Wayback Machine

[formemrs-14] "Professor Michael Brown ForMemRS". London: Royal Society. Archived from the original on November 6, 2015.

[15] "APS Member History".

[16] "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.

[17] "The Nobel Prize in Physiology or Medicine 1985". nobelprize.org. The Nobel Foundation. Retrieved October 18, 2022.

[18] "1985 Basic Medical Research Award". The Lasker Foundation. September 16, 2007. Archived from the original on September 13, 2015. Retrieved November 6, 2015.

[19] "Past ASHG Award Recipients". ASHG. Archived from the original on October 3, 2014. Retrieved November 6, 2015.

[20] "Horwitz Prize Awardees". cuimc.columbia.edu. Columbia University. June 20, 2018. Retrieved October 18, 2022.

[21] "Joseph L. Goldstein". Gairdner. Retrieved November 6, 2015.

[22] "Michael Stuart Brown". October 3, 2024.

[23] "Michael Brown". www.nasonline.org. Retrieved March 23, 2018.

[24] "Richard Lounsbery Award". Nasonline.org. Archived from the original on November 26, 2011. Retrieved November 6, 2015.

[25] Archived October 7, 2012, at the Wayback Machine

[26] "Pfizer Award in Enzyme Chemistry". Divbiolchem.org. Retrieved November 6, 2015.

[27] "Heinrich Wieland Prize Laureates 1970 - 1979". Boehringer Ingelheim Stiftung. Retrieved October 18, 2022.

v t e Laureates of the Nobel Prize in Physiology or Medicine
1901–1909	1901: Emil Behring 1902: Ronald Ross 1903: Niels Finsen 1904: Ivan Pavlov 1905: Robert Koch 1906: Camillo Golgi / Santiago Ramón y Cajal 1907: Alphonse Laveran 1908: Élie Metchnikoff / Paul Ehrlich 1909: Emil Kocher
1910–1919	1910: Albrecht Kossel 1911: Allvar Gullstrand 1912: Alexis Carrel 1913: Charles Richet 1914: Robert Bárány 1915 1916 1917 1918 1919: Jules Bordet
1920–1929	1920: August Krogh 1921 1922: Archibald Hill / Otto Meyerhof 1923: Frederick Banting / John Macleod 1924: Willem Einthoven 1925 1926: Johannes Fibiger 1927: Julius Wagner-Jauregg 1928: Charles Nicolle 1929: Christiaan Eijkman / Frederick Gowland Hopkins
1930–1939	1930: Karl Landsteiner 1931: Otto Warburg 1932: Charles Scott Sherrington / Edgar Adrian 1933: Thomas Morgan 1934: George Whipple / George Minot / William Murphy 1935: Hans Spemann 1936: Henry Dale / Otto Loewi 1937: Albert Szent-Györgyi 1938: Corneille Heymans 1939: Gerhard Domagk
1940–1949	1940 1941 1942 1943: Henrik Dam / Edward Doisy 1944: Joseph Erlanger / Herbert Gasser 1945: Alexander Fleming / Ernst Chain / Howard Florey 1946: Hermann Muller 1947: Carl Cori / Gerty Cori / Bernardo Houssay 1948: Paul Müller 1949: Walter Hess / António Egas Moniz
1950–1959	1950: Edward Kendall / Tadeusz Reichstein / Philip Hench 1951: Max Theiler 1952: Selman Waksman 1953: Hans Krebs / Fritz Lipmann 1954: John Enders / Thomas Weller / Frederick Robbins 1955: Hugo Theorell 1956: André Cournand / Werner Forssmann / Dickinson W. Richards 1957: Daniel Bovet 1958: George Beadle / Edward Tatum / Joshua Lederberg 1959: Severo Ochoa / Arthur Kornberg
1960–1969	1960: Frank Burnet / Peter Medawar 1961: Georg von Békésy 1962: Francis Crick / James Watson / Maurice Wilkins 1963: John Eccles / Alan Hodgkin / Andrew Huxley 1964: Konrad Bloch / Feodor Lynen 1965: François Jacob / André Lwoff / Jacques Monod 1966: Francis Rous / Charles B. Huggins 1967: Ragnar Granit / Haldan Hartline / George Wald 1968: Robert W. Holley / Har Khorana / Marshall Nirenberg 1969: Max Delbrück / Alfred Hershey / Salvador Luria
1970–1979	1970: Bernard Katz / Ulf von Euler / Julius Axelrod 1971: Earl Sutherland Jr. 1972: Gerald Edelman / Rodney Porter 1973: Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen 1974: Albert Claude / Christian de Duve / George Palade 1975: David Baltimore / Renato Dulbecco / Howard Temin 1976: Baruch Blumberg / Daniel Gajdusek 1977: Roger Guillemin / Andrew Schally / Rosalyn Yalow 1978: Werner Arber / Daniel Nathans / Hamilton O. Smith 1979: Allan Cormack / Godfrey Hounsfield
1980–1989	1980: Baruj Benacerraf / Jean Dausset / George Snell 1981: Roger Sperry / David H. Hubel / Torsten Wiesel 1982: Sune Bergström / Bengt I. Samuelsson / John Vane 1983: Barbara McClintock 1984: Niels Jerne / Georges Köhler / César Milstein 1985: Michael Brown / Joseph L. Goldstein 1986: Stanley Cohen / Rita Levi-Montalcini 1987: Susumu Tonegawa 1988: James W. Black / Gertrude B. Elion / George H. Hitchings 1989: J. Michael Bishop / Harold E. Varmus
1990–1999	1990: Joseph E. Murray / E. Donnall Thomas 1991: Erwin Neher / Bert Sakmann 1992: Edmond Fischer / Edwin G. Krebs 1993: Richard J. Roberts / Phillip Sharp 1994: Alfred G. Gilman / Martin Rodbell 1995: Edward B. Lewis / Christiane Nüsslein-Volhard / Eric F. Wieschaus 1996: Peter C. Doherty / Rolf M. Zinkernagel 1997: Stanley B. Prusiner 1998: Robert F. Furchgott / Louis Ignarro / Ferid Murad 1999: Günter Blobel
2000–2009	2000: Arvid Carlsson / Paul Greengard / Eric Kandel 2001: Leland H. Hartwell / Tim Hunt / Paul Nurse 2002: Sydney Brenner / H. Robert Horvitz / John E. Sulston 2003: Paul Lauterbur / Peter Mansfield 2004: Richard Axel / Linda B. Buck 2005: Barry Marshall / Robin Warren 2006: Andrew Fire / Craig Mello 2007: Mario Capecchi / Martin Evans / Oliver Smithies 2008: Harald zur Hausen / Luc Montagnier / Françoise Barré-Sinoussi 2009: Elizabeth Blackburn / Carol W. Greider / Jack W. Szostak
2011–2019	2010: Robert G. Edwards 2011: Bruce Beutler / Jules A. Hoffmann / Ralph M. Steinman (posthumously) 2012: John Gurdon / Shinya Yamanaka 2013: James Rothman / Randy Schekman / Thomas C. Südhof 2014: John O'Keefe / May-Britt Moser / Edvard Moser 2015: William C. Campbell / Satoshi Ōmura / Tu Youyou 2016: Yoshinori Ohsumi 2017: Jeffrey C. Hall / Michael Rosbash / Michael W. Young 2018: James P. Allison / Tasuku Honjo 2019: Gregg L. Semenza / Peter J. Ratcliffe / William Kaelin Jr.
2020–present	2020: Harvey J. Alter / Michael Houghton / Charles M. Rice 2021: David Julius / Ardem Patapoutian 2022: Svante Pääbo 2023: Katalin Karikó / Drew Weissman 2024: Victor Ambros / Gary Ruvkun 2025: Mary E. Brunkow / Fred Ramsdell / Shimon Sakaguchi 2026: Karl Deisseroth / Peter Hegemann / Georg Nagel

v t e 1985 Nobel Prize laureates
Chemistry	Herbert A. Hauptman (United States) Jerome Karle (United States)
Literature (1985)	Claude Simon (France)
Peace	International Physicians for the Prevention of Nuclear War (United States)
Physics	Klaus von Klitzing (Germany)
Physiology or Medicine	Michael Stuart Brown (United States) Joseph L. Goldstein (United States)
Economic Sciences	Franco Modigliani (Italy)
Nobel Prize recipients 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990

Authority control databases
International	ISNI VIAF GND FAST WorldCat
National	United States Czech Republic
Academics	ORCID
Artists	MusicBrainz
Other	Yale LUX

Michael Brown ForMemRS

Born	Michael Stuart Brown (1941-04-13) April 13, 1941 (age 85) Brooklyn, New York, U.S.
Education	University of Pennsylvania University of Pennsylvania School of Medicine
Known for	Regulation of cholesterol metabolism
Spouse	Alice Lapin (m. 1964) ^{[citation needed]}
Children	two^{[citation needed]}
Awards	Heinrich Wieland Prize (1974) Richard Lounsbery Award (1979) Louisa Gross Horwitz Prize (1984) William Allan Award (1985) Nobel Prize in Physiology or Medicine (1985) National Medal of Science (1988)
Scientific career
Fields	Biology

Website	profiles.utsouthwestern.edu/profile/10894/michael-brown.html