Mir-145

MIR145
Identifiers
AliasesMIR145, microRNA 145, MIRN145, miR-145, miRNA145, MIRN145 microRNA, human
External IDsOMIM: 611795; GeneCards: MIR145
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

406937

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Ensembl

ENSG00000276365

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UniProt

n
a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)Chr 5: 149.43 – 149.43 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human
mir-145
Conserved secondary structure of mir-145
Identifiers
Symbolmir-145
RfamRF00675
miRBase familyMIPF0000079
Other data
RNA typemicroRNA
DomainEukaryota;
PDB structuresPDBe

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility. Larsson et al. showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.

Role in cancer

miR-145 is hypothesised to be a tumor suppressor. miR-145 has been shown to be down-regulated in breast cancer. miR-145 is also involved in colon cancer and acute myeloid leukemia.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000276365 – Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Entrez Gene: MicroRNA 145". Retrieved 2015-01-26.
  4. ↑ Adammek M (2013). "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors". Fertility and Sterility. 99 (5): 1346–1355.e5. doi:10.1016/j.fertnstert.2012.11.055. PMID 23312222.
  5. 1 2 Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, et al. (Dec 2010). "miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness". Oncogene. 29 (50): 6569–6580. doi:10.1038/onc.2010.386. PMID 20818426. S2CID 11455884.
  6. ↑ Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, et al. (Nov 2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1". Genome Medicine. 1 (11) 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
  7. 1 2 Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, et al. (Jan 2011). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene". Cancer. 117 (1): 86–95. doi:10.1002/cncr.25522. PMC 2995010. PMID 20737575.
  8. ↑ Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, et al. (Mar 2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3207–3212. Bibcode:2009PNAS..106.3207S. doi:10.1073/pnas.0808042106. PMC 2651330. PMID 19202062.
  9. ↑ Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, et al. (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer". Oncology. 72 (5–6): 397–402. doi:10.1159/000113489. PMID 18196926. S2CID 207615720.
  10. ↑ Mazza T, Mazzoccoli G, Fusilli C, Capocefalo D, Panza A, Biagini T, et al. (2016-05-19). "Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer". Nucleic Acids Research. 44 (9): 4025–4036. doi:10.1093/nar/gkw245. ISSN 1362-4962. PMC 4872111. PMID 27067546.
  11. ↑ Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, et al. (Jan 2011). "Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations". Blood. 117 (2): 595–607. doi:10.1182/blood-2010-03-277012. PMID 20962326.

Further reading