Mucin-6

MUC6
Identifiers
Aliases	MUC6, MUC-6, mucin 6, oligomeric mucus/gel-forming
External IDs	OMIM: 158374; MGI: 2663233; GeneCards: MUC6
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,036,718 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,655,319 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; duodenum; ; body of stomach; ; gallbladder; ; fundus; ; sural nerve; ; islet of Langerhans; ; right lobe of liver; ; right uterine tube; ; canal of the cervix;
	Top expressed in
	duodenum; ; stomach; ; neural layer of retina; ; cerebellum; ; tail of embryo; ; skeletal muscle tissue; ; cerebellar cortex; ; human kidney; ; bone marrow; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	Golgi lumen; extracellular region; plasma membrane;
Biological process	maintenance of gastrointestinal epithelium; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4588
	353328
	ENSG00000283350; ENSG00000277281; ENSG00000184956; ENSG00000277518
	ENSMUSG00000048191
	Q6W4X9
	Q80T03; Q0VAV1
	NM_005961
	NM_181729; NM_001330001; NM_001368953
	NP_005952
	NP_859418.1; NP_001316930; NP_001355882
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-6 (MUC-6), also known as gastrin mucus-6, is a protein that is encoded in the human by the MUC6 gene. MUC6, along with MUC2, MUC5AC, and MUC5B, is located within the 11p15 chromosomal locus of chromosome 11. MUC6, along with MUC1, is expressed in normal pancreases.

In the stomach it is expressed in the antrum, in the gastric mucosa in the body, and in the deeper mucous glands of the antrum.

References

1 2 3 ENSG00000277281, ENSG00000184956, ENSG00000277518 GRCh38: Ensembl release 89: ENSG00000283350, ENSG00000277281, ENSG00000184956, ENSG00000277518 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048191 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming".
↑ Monges GM, Mathoulin-Portier MP (2005). "Role of Mucins in Pancreatic Carcinoma". Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. 3: 351–356. doi:10.1016/S1874-5784(05)80040-6. ISBN 978-0-12-088404-9.{{cite journal}}: CS1 maint: periodical has ISBN (link)
↑ "MUC6". UniProt. Retrieved 9 August 2025.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000277281, ENSG00000184956, ENSG00000277518 GRCh38: Ensembl release 89: ENSG00000283350, ENSG00000277281, ENSG00000184956, ENSG00000277518 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048191 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming".

[6] Monges GM, Mathoulin-Portier MP (2005). "Role of Mucins in Pancreatic Carcinoma". Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. 3: 351–356. doi:10.1016/S1874-5784(05)80040-6. ISBN 978-0-12-088404-9.{{cite journal}}: CS1 maint: periodical has ISBN (link)

[UniProt-7] "MUC6". UniProt. Retrieved 9 August 2025.