N-nucleotide

N-nucleotides, or nontemplated nucleotides are believed to exist only to create diversity at V(D)J junctions (see V(D)J recombination) during lymphocyte development. The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase (TdT)

References

  1. ↑ Sandor, Z; Calicchio, ML; Sargent, RG; Roth, DB; Wilson, JH (2004). "Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks". Nucleic Acids Res. 32 (6): 1866–73. doi:10.1093/nar/gkh502. PMC 390357. PMID 15047854.