Netoglitazone

Netoglitazone
Clinical data
ATC code
  • None
Identifiers
  • 5-[(6-[(2-Fluorophenyl)methoxy]naphthalen-2-yl)methyl]-1,3-thiazolidine-2,4-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.233.314 Edit this at Wikidata
Chemical and physical data
FormulaC21H16FNO3S
Molar mass381.42 g·mol−1
3D model (JSmol)
  • C1=CC=C(C(=C1)COC2=CC3=C(C=C2)C=C(C=C3)CC4C(=O)NC(=O)S4)F
  • InChI=1S/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(14)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,25) X markN
  • Key:PKWDZWYVIHVNKS-UHFFFAOYSA-N X markN
 X markNcheckY (what is this?)  (verify)

Netoglitazone (also called MCC-555) is a hypoglycemic agent belonging to the thiazolidinedione group. Netoglitazone is more than 50 times more powerful in decreasing blood glucose levels in type two diabetes than rosiglitazone, but is ten times less potent that rosiglitazone in adipogenesis. It is not used medically.

References

  1. ↑ Lazarenko OP, Rzonca SO, Suva LJ, Lecka-Czernik B (January 2006). "Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat". Bone. 38 (1): 74–84. doi:10.1016/j.bone.2005.07.008. PMC 1850100. PMID 16137931.