OSBPL11

OSBPL11
Identifiers
Aliases	OSBPL11, ORP-11, ORP11, OSBP12, TCCCIA00292, oxysterol binding protein like 11
External IDs	OMIM: 606739; MGI: 2146553; GeneCards: OSBPL11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9X
Gene location (Human)
Chr.	Chromosome 3 (human)
End	125,595,497 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,063,682 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; thoracic diaphragm; ; deltoid muscle; ; gastrocnemius muscle; ; monocyte; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; secondary oocyte;
	Top expressed in
	cumulus cell; ; gastrula; ; primary oocyte; ; secondary oocyte; ; stroma of bone marrow; ; ureter; ; primitive streak; ; Rostral migratory stream; ; zygote; ; lens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; sterol transporter activity; sterol binding;
Cellular component	endosome; membrane; late endosome membrane; nucleoplasm; Golgi apparatus; cytosol; intracellular membrane-bounded organelle;
Biological process	lipid transport; positive regulation of sequestering of triglyceride; fat cell differentiation; sterol transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	114885
	106326
	ENSG00000144909
	ENSMUSG00000022807
	Q9BXB4
	Q8CI95
	NM_022776
	NM_176840
	NP_073613
	NP_789810
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 11 is a protein that in humans is encoded by the OSBPL11 gene.

Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid transfer proteins. The protein product of the gene, ORP11, contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. It forms homo-dimers with the ORP9, the product of the OSBPL9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144909 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022807 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: OSBPL11 oxysterol binding protein-like 11".
↑ Wong LH, Gatta AT, Levine TP (February 2019). "Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes". Nature Reviews. Molecular Cell Biology. 20 (2): 85–101. doi:10.1038/s41580-018-0071-5. PMID 30337668.
↑ Cabukusta B, Borst Pauwels S, Akkermans JJ, Blomberg N, Mulder AA, Koning RI, et al. (August 2024). "The ORP9-ORP11 dimer promotes sphingomyelin synthesis". eLife. 12 RP91345. doi:10.7554/eLife.91345. PMC 11302984. PMID 39106189.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, et al. (August 2001). "The OSBP-related protein family in humans". Journal of Lipid Research. 42 (8): 1203–1213. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (December 2001). "A family of 12 human genes containing oxysterol-binding domains". Genomics. 78 (3): 185–196. doi:10.1006/geno.2001.6663. PMID 11735225.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144909 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022807 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: OSBPL11 oxysterol binding protein-like 11".

[6] Wong LH, Gatta AT, Levine TP (February 2019). "Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes". Nature Reviews. Molecular Cell Biology. 20 (2): 85–101. doi:10.1038/s41580-018-0071-5. PMID 30337668.

[7] Cabukusta B, Borst Pauwels S, Akkermans JJ, Blomberg N, Mulder AA, Koning RI, et al. (August 2024). "The ORP9-ORP11 dimer promotes sphingomyelin synthesis". eLife. 12 RP91345. doi:10.7554/eLife.91345. PMC 11302984. PMID 39106189.

OSBPL11

Function

References

Further reading